American Association for Cancer Research (AACR) |
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615 Chestnut St
17th Floor
Philadelphia
PA 19106-4404
USA
[t] +1 215 440 9300
[f] +1 215 440 9313
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The American Association for Cancer Research is a professional society of more than 24,000 laboratory and clinical scientists engaged in basic, translational, and clinical cancer research in the United States and more than 60 other countries. Founded in 1907, the AACR has as its mission to accelerate the prevention and cure of cancer through research, education, communication, collaboration and advocacy. Among the means to that end, the association publishes five major peer-reviewed scientific journals: Cancer Research – the most frequently cited cancer journal in the world – as well as Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. The AACR convenes an Annual Meeting attended by more than 15,000 scientists from around the world who share new and significant discoveries in the cancer field. Specialty meetings throughout the year focus on all the important areas of basic, translational and clinical cancer research.
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Researchers don't believe 'you are what you eat' with cancer. That disease is always a direct result of what is, or what isn't, on your dinner plate. But studies into the association between diet and cancer show that food can have an impact in preventing cancer, or in reducing the aggressiveness of the disease. |
08 July 2007 |
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Lifestyle decisions, such as smoking and consumption of fatty foods, have long been linked to increased cancer risk. During recent years, scientists have been seeking to isolate a variety of personal choices that may stave off the onset of cancer or even reduce tumor formation in their early stages. |
07 July 2007 |
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University of Nottingham researchers observed, in a clinical trial of 67 patients, that when the vaccines were administered before and after surgery to remove cancerous tumors, they helped stimulate immune cell production in up to 70 percent of patients. These results are published in the Clinical Cancer Research. |
06 July 2007 |
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According to a study published in the Cancer Epidemiology, Biomarkers & Prevention, cigarette smoking and concurrent infection with high levels of the virus associated with cervical cancer can increase cancer risk by as much as 27 times. |
05 July 2007 |
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National Cancer Institute scientists and their colleagues have introduced a new series of research articles, 'Spotlight on Molecular Profiling,' in the Molecular Cancer Therapeutics*. |
04 July 2007 |
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Researchers found, in a study of more than 36,000 women, that smokers can reduce their risk of developing lung cancer by being physically active. However, they strongly caution that any relative benefit is dwarfed by the benefits gained from quitting smoking. |
03 July 2007 |
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According to a new study by researchers at the University of Minnesota, heavy smokers who have reduced their number of daily cigarettes still experience significantly greater exposure to toxins per cigarette than light smokers. |
02 July 2007 |
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Close to half of 154 smokers who had surgery to remove early stage lung cancer picked up a cigarette again within 12 months of their potentially curative operation, and more than one-third were smoking at the one year mark, a study has found. |
01 July 2007 |
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University of Michigan Medical Center researchers have, for the first time, identified human pancreatic cancer stem cells. |
01 July 2007 |
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When mom or dad puffs on a cigarette, their infants may inhale the resulting second-hand smoke. Now, scientists have detected cancer-causing chemicals associated with tobacco smoke in the urine of nearly half the babies of smoking parents. |
30 June 2007 |
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According to researchers, expression of two different proteins taken from primary tumor biopsies is highly associated with spread of breast cancer to nearby lymph nodes. They say this protein profile could help identify at an early stage those patients whose disease is likely to metastasize. |
30 June 2007 |
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Ohio State University researchers have discovered that two microRNA molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia, the most common human leukemia in the world. |
29 June 2007 |
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According to a study published in the Clinical Cancer Research, pomegranate juice packs a punch on prostate cancer that prolongs post-surgery PSA doubling time, drives down cancer cell proliferation and causes prostate cancer cells to die. |
29 June 2007 |
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According to a study published in the Cancer Epidemiology, Biomarkers & Prevention, the risk for developing the tissue abnormalities, or lesions, that typically precede cervical cancer is much higher for women infected with multiple genotypes of the human papillomavirus than previously reported. |
28 June 2007 |
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Dartmouth Medical School researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment. |
28 June 2007 |
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University of Maryland School of Medicine researchers who are developing an inexpensive and non-invasive gene probe to help diagnose early stage lung cancer in current and former smokers say DNA coughed up along with phlegm could point to lung cancer |
27 June 2007 |
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“DES daughters,” born to mothers who used the anti-miscarriage drug diethylstilbestrol during pregnancy, are at a substantially greater risk of developing breast cancer compared to women who were not exposed to the drug in utero. |
27 June 2007 |
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A research team reported in the Cancer Research that stem cell-like glioma cancer cells that share many characteristics with normal stem cells propel the lethal growth of brain cancers by promoting tumor blood vessel formation, and may hold the key to treating these deadly cancers. |
26 June 2007 |
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According to researchers at Memorial Sloan-Kettering Cancer Center, cancer research and drug development are yielding more sophisticated candidate therapies, but investigators' methods to test them haven't kept pace. |
26 June 2007 |
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Assisted by immune system-stimulating molecules that mimic bacterial components, researchers have used a type of cancer vaccine to both delay and prevent breast tumors in mice. |
25 June 2007 |
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According to researchers at Memorial Sloan-Kettering Cancer Center, cancer research and drug development are yielding more sophisticated candidate therapies, but investigators' methods to test them haven't kept pace. That could explain why so many experimental drugs fail in the final large and costly phase of testing, they say. |
25 June 2007 |
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According to a study led by researchers at Northwestern and Harvard universities, consumption of Vitamin D tablets was found to cut the risk of pancreatic cancer nearly in half. |
24 June 2007 |
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According to a study, Raloxifene protects postmenopausal women from developing invasive breast cancer whether they are at high or low risk of developing the disease. |
23 June 2007 |
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Purdue University researchers have found a protein in the blood that may prove to be more reliable than the standard prostate specific antigen test in measuring the extent of prostate cancer. |
22 June 2007 |
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As diseases go, lung cancer is one of the most formidable. While it is one of the most preventable cancers, with the vast majority of 160,000 annual deaths in the United States due to smoking, it is invariably difficult to find early when it is most amenable to treatment. As a result, it remains the top cancer killer in the nation. |
21 June 2007 |
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According to a new study from the Max Delbrueck Center in Berlin, Germany, two genes, known as REG1A and EXTL3, are overexpressed in colorectal tumors of patients who are at high risk of recurrence. |
20 June 2007 |
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Patients with melanoma of the eye are at risk for liver metastases, which are often not detected until they have turned into large, lethal tumors. Now researchers have found molecular markers, including changes in a particular chromosome, that flag the presence of small metastases before they reach life-threatening size. |
19 June 2007 |
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According to research presented at the first international meeting on Molecular Diagnostics in Cancer Therapeutic Development, organized by the American Association for Cancer Research, in the U.S. a novel technology soon may be available to detect the spread, or metastasis, of breast cancer earlier than now possible. |
18 June 2007 |
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A Maryland-based pharmaceutical company has preliminary evidence showing that a protein in the blood may prove to be a biomarker that is more sensitive and specific than current methods of early detection for prostate cancer. |
17 June 2007 |
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Scientists have devised a new method to detect a spectrum of known gene mutations in a variety of cancer genes that they say is both sensitive and cost-effective. They say that if validated, this method of genotyping might ultimately be used in “real time” to match patients to available targeted therapies. |
16 June 2007 |
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University of Michigan Medical Center scientists have, for the first time, identified human pancreatic cancer stem cells. Their work indicates that these cells are likely responsible for the aggressive tumor growth, progression, and metastasis that define this deadly cancer. |
16 June 2007 |
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According to a study at Yale University School of Medicine, levels of a protein called thymidylate synthase within two separate compartments of a tumor cell, the nucleus and the cytoplasm, may be critical markers predicting survival in colorectal cancer. |
15 June 2007 |
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According to accumulating evidence, angiogenesis inhibitors can be far more effective in treating metastatic clear cell renal cell cancer, an aggressive form of the most common kind of kidney cancer that is also rich in blood supply, than traditional treatments. They can prolong life in about a third of patients, but researchers have not been able to identify the responding patients, prior to treatment. |
14 June 2007 |
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A routine laboratory test that predicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers has now been found to predict a good prognosis with treatment of p53 tumor suppressor gene therapy, making it potentially the first predictive biomarker test for a gene-based drug. |
13 June 2007 |
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Scientists have discovered that the same gene mutation responsible for a tepid response to Gleevec (imatinib) in treatment of gastrointestinal stromal tumors, bestows benefit when a newer targeted therapy, Sutent (sunitinib), is used. |
12 June 2007 |
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According to National Cancer Institute research, if an anti-angiogenic drug is successfully starving a cancer patient’s tumor to death, the number of endothelial cells circulating in the individual’s bloodstream will decrease, thus providing a potential biomarker for gauging the medication’s effectiveness. |
11 June 2007 |
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According to researchers, a test that measures the amounts of 2 members of the same protein family, one of which appears to act as an oncogene, and the other as a tumor suppressor, helps identify patients with breast cancer who will likely benefit from chemotherapy and those who won’t. |
10 June 2007 |
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According to a report in journal Cancer Research, achemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice, suggesting that the compound in pill form could be used to treat human metastatic cancer. |
09 June 2007 |
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According to researchers who have already demonstrated the extract's anti-cancer effects in other tumor types, chemicals in grape seeds significantly inhibited growth of colorectal tumors in cell cultures & mice |
08 June 2007 |
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For younger women, the best initial cervical cancer screening tool is still the traditional Pap smear. However, a large Danish study has found that for older women (age 40 and older), a test for HPV is a much more effective way to screen for potential cancer. |
07 June 2007 |
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A specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species in the prostate gland that play a role in the development of prostate cancer has been discovered by scientists for the first time . They found that a drug that blocks this pathway significantly prolonged survival and inhibited tumour development in mice that were genetically engineered to spontaneously develop prostate cancer and die of the disease. |
06 June 2007 |
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American researchers have found that vaccinating mice with embryonic stem cells prevented lung cancer in those animals that had cancer cells transplanted into them after the vaccination or that had been exposed to cancer-causing chemicals. |
05 June 2007 |
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Early tests of a MEK enzyme inhibitor have shown that it can produce long-lasting stable disease in patients with advanced solid cancers. Trials showed that the drug inhibited key targets in the patients' tumours, and now it is being tested in phase II clinical trials. |
04 June 2007 |
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Researchers who are studying ways of prompting the immune system to recognise and kill tumour cells have found that a drug containing parts of the diptheria toxin appears to work well in patients with advanced melanoma (skin cancer). In the first part of a phase II clinical trial to test the drug denileukin diftitox, also known as DAB(389)IL2 or ONTAK, in melanoma five out of seven patients with stage IV disease experienced significant regression or stabilisation of both tumours and metastases. The two other patients in whom the disease progressed were on a lower dose of the drug. All the patients are still alive after one year. |
03 June 2007 |
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Initial results from a phase II clinical trial have shown that treating patients with kidney cancer with bevacizumab and erlotinib1 prior to surgery is safe, effective and may extend patients' survival. |
02 June 2007 |
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Researchers say they can now detect 'cancer genes' in the breath of smokers, and also test the presence of two proteins in men they say will predict development of prostate cancer a decade in advance. Scientists at the American Association for Cancer Research's Frontiers say ths shows how it is becoming increasingly possible to use genes and their protein products to help predict and diagnose cancer, as well as choose therapy that offers the most potential for a good result. |
01 June 2007 |
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A new way has been found that can find and destroy prostrate cancer by using a protein. The new treatment studies show that it only affected the prostate and did not affect any other tissue. |
01 June 2007 |
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American researchers have discoverd that a combination of a drug that induces cell death (apoptosis) and imantanib (Glivec1) has returned an improved performance at proventing the growth of Ewing's sarcoma in mice than either therapy on its own. |
01 June 2007 |
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A diagnosis of breast cancer has taken on a new meaning in the past 10 years, as research has produced a host of new therapies and detection techniques, significantly improving long-term survival for women who have been fighting the disease. To build on these successes, researchers are now harnessing what they have learned about treating breast cancer and applying it to possible methods of prevention to reduce the total incidence of the disease. |
30 May 2007 |
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Human papillomaviruses are the most common sexually transmitted infections in the United States, and certain 'high risk' types have been shown to cause cervical cancer. Despite recent advances in the detection and prevention of HPV, the link between the virus and cervical cancer is not well known to the public. The Food and Drug Administration approved the first vaccine to prevent infection of two high risk types of HPV, and two types that cause genital warts. The Advisory Committee on Immunization Practices recommended it for females 9 to 26 years of age. |
28 May 2007 |
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Scientists are using genetic studies and natural chemicals, such as plant-derived triterpenoids, to further our knowledge on how genetic and early molecular interactions can lead to cancer, and how those early interactions can be manipulated to stave off a variety of cancers. The latest studies with new and promising chemopreventive agents were presented at the American Association for Cancer Research's Frontiers in Cancer Prevention Research meetinG. |
27 May 2007 |
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Taking celecoxib, a COX-2 inhibitor better known as Celebrex, has been found to alter a specific 'signature' set of genes in the colons of patients at high risk for a hereditary form of colon cancer, according to a new study reported here at the 96th Annual Meeting of the American Association for Cancer Research. |
16 July 2006 |
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Combinations of Lipitor and Celebrex (celecoxib) at lower doses proved more effective at limiting colon cancer than higher doses of the drugs when given alone, according to research reported at the 96th Annual Meeting of the American Association for Cancer Research here today. |
15 July 2006 |
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In mouse models of intestinal cancer, use of an anti-inflammatory drug eliminated all of the cancer-causing risks produced by a high-fat Western-style die, even when several genetic brakes to cancer formation were missing in the animals, say researchers from the Albert Einstein Cancer Center. |
15 July 2006 |
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Screening for breast cancer and the early detection of other tumors one day may be as simple as spitting into a collection tube or cup, according to recent studies by UCLA researchers. In one early study based on a risk model, presented here at the 96th Annual Meeting of the American Association for Cancer Research, the UCLA scientists reported that genetic 'biomarkers' isolated in saliva predicted oral squamous cell carcinoma in about nine out of 10 cases. |
14 July 2006 |
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Use of such cholesterol-lowering drugs as statins may reduce the risk of advanced prostate cancer, according to research that followed 34,428 U.S. men for more than a decade. The study, presented at the 96th Annual Meeting of the American Association for Cancer Research, found that men who used these medications had half the risk of advanced prostate cancer and a third of the risk of metastatic or fatal prostate cancer, compared to men who did not use cholesterol-lowering drugs. Risk of advanced prostate cancer fell with increasing duration of use of the drugs. The study did not find that use of cholesterol-lowering drugs had any influence on prostate cancer that is confined within the organ. |
14 July 2006 |
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Greater levels of selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males, those who inherit a specific genetic variation that's particularly sensitive to oxidative stress. Conversely, if carriers of this genetic variant have low levels of these vitamins and minerals, their risk of aggressive prostate cancer increases substantially, as great as 10-fold, over their cohorts who maintain higher levels of these nutrients. |
13 July 2006 |
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A novel delivery system that transports gene silencing nanoparticles into tumor cells has been shown to inhibit Ewing's sarcoma in an animal model of the disease. In this classic 'Trojan horse' approach, a protein called transferrin that normally delivers iron into cells is modified to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The siRNA was designed to target a specific growth-promoting gene called EWS-FLI1 that's active only in Ewing's sarcoma tumors. |
13 July 2006 |
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A novel delivery system that transports gene silencing nanoparticles into tumor cells has been shown to inhibit Ewing's sarcoma in an animal model of the disease.
In this classic 'Trojan horse' approach, a protein called transferrin that normally delivers iron into cells is modified to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The siRNA was designed to target a specific growth-promoting gene called EWS-FLI1 that's active only in Ewing's sarcoma tumors. |
12 July 2006 |
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Cancer screening tests can frequently produce false positive outcomes that may result not only in anxiety but also additional economic costs as well, according to research conducted by scientists at the Henry Ford Health System, Detroit, Mich., and published in the December issue of Cancer Epidemiology, Biomarkers & Prevention. |
12 July 2006 |
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The polyphenols present in green tea help prevent the spread of prostate cancer by targeting molecular pathways that shut down the proliferation and spread of tumor cells, as well as inhibiting the growth of tumor nurturing blood vessels, according to research published in the December 1 issue of Cancer Research. |
11 July 2006 |
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After a year's oral administration of green tea catechin, only one man in a group of 32 at high risk for prostate cancer developed the disease, compared to nine out of 30 in a control, according to a team of Italian researchers from the University of Parma and University of Modena and Reggio Emilia led by Saverio Bettuzzi, Ph.D. |
11 July 2006 |
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The pain and suffering of a broken bone may yield an unexpected benefit, a reduced risk of ovarian cancer. According to a new study reported in the May issue of Cancer Epidemiology, Biomarkers & Prevention, this unlikely pairing of unfortunate life events has a common thread: a protein called MUC1. What's more, this knowledge may offer new insights into a vaccine against ovarian cancer. |
10 July 2006 |
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The anti-inflammatory drug Celebrex, or celecoxib, reduces tumor mass by encouraging cell death and discouraging both cell proliferation and the sprouting of new blood vessels that feed growing tumors, according to a study reported in the November issue of Molecular Cancer Research. |
10 July 2006 |
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They're but a tiny speck, existing in a variety of forms: particles, tubes, shells, even a soccerball-like shape. They also share a common prefix: 'nano,' connoting their size, a billionth of a meter or roughly 25-millionth of an inch. Cancer researchers are exploring the potential of such nanostructures to exquisitely target cancer cells without harming surrounding tissue, and to image the formation of tumors long before they have a chance to become life-threatening. While diagnostics and approved therapies are years away, several are nearing clinical studies, while a few already are being tested in patients. |
09 July 2006 |
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The American Association for Cancer Research extends its thoughts and heartfelt sympathies to all the citizens of New Orleans and other Gulf Coast communities as they rebuild their lives in the aftermath of Hurricane Katrina. In particular, the AACR wishes to assist its members and other cancer researchers in the region whose personal and professional lives have been devastated by this disaster. Valuable research that one day could save lives from cancer has been placed in jeopardy. |
09 July 2006 |
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Updated data from a study on a promising new vaccine against a pre-cancerous cervical virus shows superior efficacy in preventing cervical pre-cancers and non-invasive cervical cancer, according to a study presented today during the American Association for Cancer Research's 4th Annual Frontiers in Cancer Prevention Research meeting in Baltimore. |
08 July 2006 |
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A second look at compounds and drugs, some previously used to treat illness and conditions ranging from malaria to contraception, is giving new life to several abandoned therapies and new applications for existing drugs. From drugs such as the cottonseed extract gossypol, once tested as a male contraceptive in China, to arsenic, which can be made less toxic in an organic form, new applications are being investigated for effectiveness against solid tumors of various types. |
08 July 2006 |
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The cosmetic treatment Botox may have a new use as an adjuvant to cancer therapy, providing an open door for chemotherapy and radiation treatments, according to a study published in the Feb. 15 issue of Clinical Cancer Research. |
08 July 2006 |
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Cancer researchers wielding opportunistic bacteria, vaccines, electric pulses, nano buckeyballs, and designer agents that enter the brain are being featured in a 'Novel Approaches' press conference at the Molecular Targets and Cancer Therapeutics International Conference. |
07 July 2006 |
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In a group of high-risk patients, a test that examined DNA from cells expelled in sputum for evidence of 'silenced' genes correctly identified the majority of patients who were later diagnosed with lung cancer, say researchers in a study published in the March 15 issue of Cancer Research. |
07 July 2006 |
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Men with a high intake of dietary calcium are at greater risk of developing prostate cancer, according to a study presented today during the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore. |
07 July 2006 |
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Though scientists have long suspected that diet and obesity play a significant role in cancer risk, the latest results are suggesting the problem may be more serious than previously thought. Updated population studies suggest that the projected burden of cancer resulting from overweight and obesity may thwart other efforts to reduce cancer incidence over the next couple of decades, including curtailment of smoking. |
06 July 2006 |
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Updated population studies suggest that the projected burden of cancer resulting from overweight and obesity may thwart other efforts to reduce cancer incidence over the next couple of decades, including curtailment of smoking. |
06 July 2006 |
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The drug gefitinib (Iressa) was approved by the U.S. Food and Drug Administration in May 2003 under the agency's accelerated approval program for the treatment of patients with non-small cell lung cancer who had failed two or more courses of chemotherapy. Consistent with the requirements of accelerated approval, the sponsoring company continued to study the drug to verify the expected clinical benefit. In December 2004, the FDA released a statement notifying the failure of a large clinical trial of gefitinib to show an overall survival advantage compared to placebo in treating patients with lung cancer. In June 2005, FDA issued a new label for gefitinib 'that limits use to patients with cancer who in the opinion of their treating physician, are currently benefiting, or have previously benefited, from Iressa treatment.' |
06 July 2006 |
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Capsaicin, the stuff that turns up the heat in jalapeños, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, according to studies published in the March 15 issue of Cancer Research. According to a team of researchers from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, in collaboration with colleagues from UCLA, the pepper component caused human prostate cancer cells to undergo programmed cell death or apoptosis. |
06 July 2006 |
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Results from a Phase III study of a new drug show promise for patients with colorectal cancer that has spread to other parts of the body, according to a study presented today during the 97th Annual Meeting of the American Association for Cancer Research. |
05 July 2006 |
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Since smoking became popular in America in the 1930s, lung cancer rates have continued to climb. Today, it is still the leading cause of cancer-related deaths, with totals more than the other five leading cancers combined. Armed with these sobering statistics, scientists have launched several innovative projects to find therapies that will effectively treat, and hopefully reduce the overall incidence of lung cancer. Several are being presented today during the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore. |
05 July 2006 |
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In the high-tech 21st century, the most rudimentary natural products continue to reveal exciting anti-cancer properties to scientists, offering people relatively simple ways to help protect themselves from the disease. |
05 July 2006 |
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According to the U.S. Centers for Disease Control and Prevention, nearly one-fourth of Americans are smokers. That's more than 60 million people who are at increased for lung cancer, the leading cause of cancer-related deaths nationwide. |
04 July 2006 |
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One of the goals for cancer prevention is to identify, as early as possible, molecular changes in the body that signal the onset of disease. Such 'biomarkers' may be isolated from subtle biological changes in an individual's cells, proteins or genetic makeup. Useful biomarkers to help prevent, diagnose and monitor treatment for cancer must share two essential characteristics: they must be consistently reliable, and they must display significant difference in expression between normal tissue and the various stages of cancer progression. |
04 July 2006 |
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A study led by researchers from the Howard Hughes Medical Institute has found that dasatinib provides significant benefit in chronic myeloid leukemia patients resistant to Gleevec (imatinib), according to a study presented today during the 97th Annual Meeting of the American Association for Cancer Research. |
04 July 2006 |
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During the past year, the study of the potential use of cyclooxygenase-2 inhibitors to prevent colorectal and breast cancer has come under intense scrutiny. Recent research questioned the safety of these medicines as pain relievers, which was the initial indication, as well as for chemoprevention of cancer. Now, the latest data show that COX-2 inhibitors are highly effective in preventing pre-malignant tumors of the colon, and therefore may be useful in preventing colorectal cancer among high-risk patients. |
03 July 2006 |
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One of the goals for cancer prevention is to identify, as early as possible, molecular changes in the body that signal the onset of disease. Such 'biomarkers' may be isolated from subtle biological changes in an individual's cells, proteins or genetic makeup. |
03 July 2006 |
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Researchers have been trying to develop methods to identify why certain individuals are more susceptible to cancer and from these insights, determine the molecular causes of the disease. Based on these results, scientists are now seeking to pinpoint compounds that can reduce the incidence or recurrence of cancer, a field of study known as chemoprevention. Several studies presented today at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore are focusing on new directions in this promising new field. |
03 July 2006 |
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There are a number of things people are told to do to prevent cancer, eat well, exercise, don't smoke. However, despite these obvious preventive measures, many individuals will develop the disease. |
03 July 2006 |
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Long term use of L-thyroxin, the principal hormone secreted by the thyroid gland, reduces the risk of colorectal cancer by 50 percent, according to a study presented today at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore. |
02 July 2006 |
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Molecular messages and signals circulating in blood or contained in cells lining the airway can identify early stage cancer, according to scientists presenting today at the 97th Annual Meeting of the American Association for Cancer Research in Washington, D.C. Researchers have discovered molecular signposts pointing to the presence of cancer, and those signs can provide physicians with early and, in some cases, more specific cancer detection opportunities. The goal of screening and early detection is to identify primary tumors at initial stages of development when they can be successfully controlled or cured with local therapy. |
02 July 2006 |
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Promising new ways to prevent cancer emerge regularly from the laboratories of research institutions around the world. With every deposit to the scientific bank of knowledge about the human body and disease processes comes an opportunity to posit and test fresh theories. The results often suggest simple measures people can take to improve their chances of cheating cancer. |
02 July 2006 |
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Inflammation cuts both ways. When invaded by an infectious agent, for example, the body calls on the forces of inflammation to fight and defeat the intruder. But when the biochemical processes of the immune system are either misdirected or chronically turned on, inflammation can lead to adversity, including some forms of cancer. For this reason, scientists are closely studying the link between inflammatory processes and tumor formation, while others are investigating anti-inflammatory drugs as a means to prevent and treat cancer, as seen by studies presented today at the 97th Annual Meeting of the American Association for Cancer Research. |
01 July 2006 |
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Researchers are delving deeper into the links between smoking and cancer, teasing out the genes and molecules involved as well as other factors that affect cancer risk. They have found, for example, a specific protein that decreases with smoking cessation. Genetic factors are also being implicated in the lung cancers of people who have never smoked. New studies are revealing an association between smoking and ovarian cancer, as well as between second-hand smoke exposure and lung cancer survival. |
30 June 2006 |
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While risk factors for breast and ovarian cancers include menopause, obesity, family history and specific genetic mutations, researchers also are looking at the role of diet in the development, as well as the treatment and prevention of these tumors. At the 97th Annual Meeting of the American Association for Cancer Research, two groups of scientists using sophisticated statistical techniques report their findings of possible preventive properties of Vitamin D against breast cancer. |
29 June 2006 |
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Conventional cancer treatments are generally effective in wiping out tumor cells, but in the process they also may kill healthy cells. Researchers are focusing their efforts now on treatments that can target just the cancerous cells, without harming healthy tissue in their midst. These new types of drugs are known as targeted therapies, and physicians are studying their effectiveness and possible side effects in a variety of different types of cancer. Several targeted therapies are being studied alone and in combination to treat a variety of cancer types. In particular, cancerous brain tumors can be more difficult to treat than other cancers, and oncologists are developing therapies that target these cells to improve patients' survival. |
28 June 2006 |
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Cancer researchers are working toward a future in which each patient's tumor will act like a crystal ball, revealing how oncologists should treat the cancer to obtain the best outcome. Currently, physicians cannot predict which patients with prostate cancer should receive extra therapy after surgery; or whether some of these patients have an indolent disease that does not even require surgery. Most patients with colorectal cancer have surgery, but some, even at the earliest stages, could benefit from additional treatment, if physicians only knew who. |
27 June 2006 |
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Researchers at the University of California, Los Angeles have defined conditions associated with disabling fatigue that persists for years in almost a third of breast cancer survivors, according to a study in the May 1 issue of Clinical Cancer Research. |
26 June 2006 |
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Scientists have found some additional evidence that environmental exposure to polychlorinated biphenyls may be associated with non-Hodgkin lymphoma, according to a study published in the December 1 issue of Cancer Research. By comparing blood levels of PCBs in 100 pairs of healthy volunteers and non-Hodgkin lymphoma patients, Anneclaire De Roos, Ph.D., assistant professor of epidemiology, Fred Hutchinson Cancer Research Center, and colleagues determined that high levels of three specific molecular forms of PCBs are linked to an increased risk of developing cancer that starts in patients' lymph tissue. |
09 June 2006 |
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According to two studies presented today at the 97th Annual Meeting of the American Association for Cancer Research, the over-expression of the COX-2 enzyme is related to the growth and spread of colorectal tumors. COX-2 inhibitors may reduce the occurrence of the precursor, colorectal adenomas (benign tumors) in patients with a family history of the disease, as well as the development of sporadic colorectal tumors. |
05 June 2006 |
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Imatinib, which blocks the irregular protein that allows the overproduction of abnormal white blood cells, has become a standard therapy for CML patients not undergoing stem cell transplantation. However, a number of patients have developed resistance to this treatment because their cancer cells are able to mutate and adapt. |
31 March 2006 |
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A study in mice, led by Bernard Gallez, Ph.D., professor of pharmacy at the Université de Louvain in Brussels, Belgium, found that by injecting Botulinum neurotoxin type A into two types of mouse tumors, the tumors' cellular vasculature opened, allowing for more effective destruction of previously resistant cancer cells. The study is the first to test the idea of using Botox against cancer and explores the possibility of its use as an adjuvant, assisting the effective delivery of chemotherapies and radiation. |
28 March 2006 |
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Oncologists believe that Iressa still holds promise and continue investigating its potential. Several studies presented at the Annual International Conference on Molecular Targets and Cancer Therapeutics coordinated by the American Association for Cancer Research, the National Cancer Institute and the European Organisation for Research and Treatment of Cancer explore the ways in which gefitinib may work on tumors and which patients may benefit the most. |
03 February 2006 |
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Researchers have been trying to develop methods to identify why certain individuals are more susceptible to cancer and from these insights, determine the molecular causes of the disease. Based on these results, scientists are now seeking to pinpoint compounds that can reduce the incidence or recurrence of cancer, a field of study known as chemoprevention. Several studies presented today at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore are focusing on new directions in this promising new field. |
12 December 2005 |
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Useful biomarkers to help prevent, diagnose and monitor treatment for cancer must share two essential characteristics: they must be consistently reliable, and they must display significant difference in expression between normal tissue and the various stages of cancer progression. |
31 October 2005 |
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Use of L-thyroxin, which is commonly used to treat hypothyroidism, for five or more years was associated with a significantly reduced risk of colorectal cancer
across study participants of all genders, ages, origins and religions, but reached statistical significance in Jewish females, participants aged 65 and older, and European-American born participants, which were the largest study sub-populations. |
28 October 2005 |
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Despite the risks, many people have trouble kicking this addictive habit of smoking. As a result, health officials and doctors are trying to find less harmful alternatives to cigarette smoking. But some products, like smokeless tobacco, may not be effective replacements, according to research presented today during the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore. |
30 July 2005 |
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Final results of the phase III study, originally published in early October, confirmed the vaccine's efficacy from available combined phase II and phase III data sets, incorporating an additional 7,000 patient records as compared to the interim results. The researchers concluded from these analyses that the administration of this vaccine, known as GARDASIL, is highly effective in preventing high-grade pre-cancerous illnesses and non-invasive cervical cancers. |
08 July 2005 |
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Five studies presented during the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore, Md., add to the arsenal of research that shows adding certain vegetables and herbs to the diet can prevent or, in some cases, halt the growth of cancer. |
05 July 2005 |
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Researchers from the Division of Cancer Epidemiology and Genetics of the National Cancer Institute reviewed data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study to evaluate the relation between calcium, vitamin D, phosphorus as well as dairy products and occurrence of prostate cancer. The current research was based on 17 years of follow-up and 1269 incident cases of prostate cancer. |
07 January 2005 |
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An oestrogen-like chemical commonly used to synthesize plastic food containers has been shown to encourage the growth of a specific category of prostate cancer cell, potentially affecting the treatment efficacy for a subset of prostate cancers. |
03 January 2005 |
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A Stony Brook University researcher is testing a new form of aspirin, one that is much more potent than its commercially available counterpart, but with almost none of the side effects, to determine whether it can be used to prevent colon cancer in patients who are prone to the disease. |
19 October 2004 |
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A common antibacterial and antifungal ingredient used in mouthwashes and tooth paste may have another positive medicinal use: protection against skin cancer. According to new studies, sanguinarine was shown to enhance production of proteins that induce cell death, or apoptosis, in cells damaged by ultraviolet-B radiation. The alkaloid also restricts skin cell production of other pro-proliferation proteins. |
19 October 2004 |
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Fred Hutchinson Cancer Research Center's Public Health Sciences Division houses the Clinical Coordinating Center for the Women's Health Initiative, or WHI, one of the largest National Institutes of Health-funded studies ever conducted in women. This 15-year, multimillion-dollar study, established in 1991, involves more than 160,000 women nationwide, including some 3,500 in Washington. |
18 October 2004 |
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A commonly prescribed drug used to treat gout may also offer some protection against colorectal cancer, according to a new study reported during the American Association for Cancer Research Third Annual International Conference on Frontiers in Cancer Prevention Research here. |
18 October 2004 |
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Researchers from the Keck School of Medicine of the University of Southern California in Los Angeles, the University of Hawaii in Honolulu, and the University of Helsinki in Finland have shown that, in Mexican American women, higher intake of dietary fiber is associated with lower circulating estrogen levels. Because high estrogen levels have been linked to breast cancer, this finding could provide a significant step toward preventing breast cancer. |
18 October 2004 |
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Researchers from the Keck School of Medicine of the University of Southern California in Los Angeles, the University of Hawaii in Honolulu, and the University of Helsinki in Finland have shown that, in Mexican American women, higher intake of dietary fiber is associated with lower circulating estrogen levels. Because high estrogen levels have been linked to breast cancer, this finding could provide a significant step toward preventing breast cancer. |
18 October 2004 |
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The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study was initiated to test the effect of vitamin supplementation on the prevention of lung and other cancers. The trial ended in 1993, but ongoing follow-up of the participants continues, offering new insights into the causes and prevention of multiple diseases, including cancer. |
17 October 2004 |
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Disease Prevalence in Taiwan Corresponds to Increased Production of Betel Quid, a Nut Common to Asia and Infamous for Its Intoxicating Effects upon Chewing
SEATTLE, Over the past couple of decades, scientists have been perplexed by a substantial rise in the incidence of head and neck cancers among Taiwanese men. According to cancer statistics, the disease increased by 85 percent among men there from 1981 to 2000. |
17 October 2004 |
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Geneva, Switzerland: New research from the United States has opened up the prospect that gossypol, a drug refined from cottonseed oil and previously tried and abandoned as a male contraceptive, could boost the effectiveness of treatment for prostate tumours and possibly other common cancers as well. |
01 October 2004 |
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Acne is not a condition that anyone would welcome under normal circumstances, but an international study of a new targeted cancer treatment, cetuximab, has shown that patients who developed an acne-like rash responded better to the treatment than those who did not. |
30 September 2004 |
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An international team of scientists and cancer specialists has identified which
patients with the deadly form of brain tumours called glioblastomas are likely to live longer if they are treated with temozolomide, and which patients are likely to get only marginal, if any, benefit. |
29 September 2004 |
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Arsenic trioxide, a highly poisonous substance best known as an effective weed killer or pesticide and notorious for being a favourite 'weapon' of choice in murder mystery novels, is being re-invented as a treatment for a rare type of leukaemia. |
29 September 2004 |
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Carb-conscious dieters may be lowering their risk of breast cancer while they're shedding pounds, based on the findings of research published in this month's edition of the journal Cancer Epidemiology, Biomarkers & Prevention. |
06 August 2004 |
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Children who undergo chemotherapy and survive acute lymphocytic leukemia endure a 200-fold increase in the frequency of somatic mutations in their DNA, researchers from the University of Vermont Medical School reported in the July 1 issue of the journal Cancer Research. |
07 July 2004 |
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Diabetics are three times more likely to develop colorectal cancer than people with normal blood sugar levels, according to a team of scientists at the University of Cambridge, U.K., reporting in this month's edition of the journal Cancer Epidemiology, Biomarkers and Prevention. |
04 June 2004 |
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Researchers have combined novel molecular targeting technologies to deliver gene-silencing therapy specifically to tumor cells shielded by a normally impermeable obstacle, the blood brain barrier. |
01 June 2004 |
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Researchers find new purpose for existing drugs to suppress colon cancer metastasis, secure post-radiation brain function, and trick tumors to gorge on a Trojan Horse vitamin. Drugs approved for treatment of specific maladies sometimes show unexpected benefits. Researchers at the 95th annual meeting of the American Association for Cancer Research highlighted how some drugs may one day offer previously unforeseen benefits for patients. |
30 March 2004 |
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Emil Frei III, M.D., who revolutionized chemotherapy and advanced the treatment of cancer worldwide, has received the inaugural American Association for Cancer Research Award for Lifetime Achievement in Cancer Research. |
28 March 2004 |
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Early clinical studies show that a new generation of drugs that target signaling pathways, the internal channels through which cancer cell growth is controlled, and the body's own production of tumor-suppressing proteins hold promise for the treatment of a variety of tumors. Patient trials evaluated drug tolerance and potential anti-tumor activity against a variety of cancers such as renal cell, colorectal and non-Hodgkin's lymphoma of three compounds. |
20 November 2003 |
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Scientists today reported exciting discoveries to optimize existing cancer treatments. One set of studies demonstrated that the cell-killing effects of either radiation or standard chemotherapy drugs were enhanced when tumor cells such as melanoma were grown in dishes containing PABA, an ingredient in some sunscreens. |
19 November 2003 |
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Scientists today presented studies of proteomic and genomic markers that could help oncologists devise better treatment approaches for specific patients, and may improve clinical outcomes. The studies were presented here today at the International Conference on Molecular Targets and Cancer Therapeutics organized by the American Association for Cancer Research, National Cancer Institute and European Organisation for Research and Treatment of Cancer. |
19 November 2003 |
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Scientists announced today that they have discovered a protein produced by advanced childhood cancers that provide s a new target for treatments and a new marker for the disease. Separately, researchers reported data on the crystal structures of two kinase proteins implicated in multiple cancers. The data on structure provides valuable information for the design of cancer therapeutics targeted at these proteins. |
19 November 2003 |
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A tumor's growth may be controlled by a complex, gene-controlled 'clock, and jamming that 'clock' can offer a new way to fight cancer, according to two studies presented today at the International Conference on Molecular Targets and Cancer Therapeutics organized by the American Association of Cancer Research, National Cancer Institute and European Organisation for Research and Treatment of Cancer in Boston. |
18 November 2003 |
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Drinking green tea may do more than just thwart a head cold, according to research presented today at the American Association for Cancer Research Second Annual International Conference on Frontiers in Cancer Prevention Research. Green tea already is believed to help lower cholesterol and prevent heart disease, fight bacteria and dental cavities, and possibly aid weight loss. New studies are now suggesting the various potential anti-cancer benefits of the age-old beverage. |
28 October 2003 |
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Common spices and herbs contain ingredients that may prevent the formation of major tumors, such as intestinal and prostate cancers, according to research presented today at the American Association for Cancer Research's Second Annual International Conference on Frontiers in Cancer Prevention Research. In particular, recent studies are showing notable cancer prevention potential for the use of ginger extract and a traditional Chinese medicinal herb. |
28 October 2003 |
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Two new therapies for metastatic cancer are showing significant clinical activity, according to research presented today at the 94th Annual Meeting of the American Association for Cancer Research. The studies examined the potential anti-tumor benefits of a combination therapy for colorectal cancer and a multi-targeted oral therapy for imatinib-resistant gastrointestinal stromal tumors. |
14 July 2003 |
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Armed with information about the function and capabilities of currently approved cancer therapies, researchers are beginning to develop more potent and successful treatments, according to research presented today at the 94th Annual Meeting of the American Association for Cancer Research. |
12 July 2003 |
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Researchers have identified a new gene, C35, that appears to be closely associated with breast cancer. Of the breast cancer tissues tested, more than sixty percent over-expressed the C35 gene, according to data published in the Proceedings for the 94th Annual Meeting of the American Association for Cancer Research. The study also found that the C35 gene was only over-expressed in breast cancer cells, and is not evident in any normal tissues in women. |
08 April 2003 |
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Regular use of ibuprofen and aspirin inhibits the formation and growth of breast cancer, according to data published in the Proceedings for the 94th Annual Meeting of the American Association for Cancer Research. The data, taken from the National Cancer Institute's Women's Health Initiative Observational Study, concluded that weekly doses of non-steroidal anti-inflammatory drugs had a significant effect in reducing the risk of breast cancer. |
08 April 2003 |
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