Washington University in St Louis |
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Alumni House
Box 1070
St. Louis
MO 63130
+1
[t] 314-935-5272
[f] 314 935-4259
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Washington University in St. Louis is a medium-sized, independent research university dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The university is counted among the world's leaders in teaching and research and draws students and faculty to St. Louis from all 50 states and more than 90 other nations. With 6,509 undergraduates and 5,579 graduate and professional students, as well as 1,384 part-time students, Washington University offers more than 90 programs and nearly 1,500 courses in a broad spectrum of traditional and interdisciplinary majors.Founded in 1853 by St. Louisans, Washington University is highly regarded for its commitment to excellence in learning. Its programs, administration, facilities, resources, and activities combine to further its mission of teaching, research, and service to society. Set amid a thriving metropolitan region of 2.6 million residents, the University benefits from the vast array of social, cultural, and recreational opportunities offered by the St. Louis area. Bordered on the east by St. Louis' famed Forest Park and on the north, west, and south by well-established suburbs, the 169-acre Hilltop Campus features predominantly Collegiate Gothic architecture, including a number of buildings on the National Register of Historic Places. |
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The United States Department of Health and Human Services announced today that Washington University School of Medicine in St. Louis will anchor a multi-institutional Midwest Regional Center for Excellence in Biodefense and Emerging Infectious Diseases Research. The center will be funded by a five-year, $35 million grant from the National Institute of Allergy and Infectious Diseases. |
27 August 2006 |
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Mice lacking only one copy of the gene for CD2-associated protein appear to be significantly more susceptible to kidney disease and failure than normal mice. Moreover, the mutation appears to impair the elimination of proteins that accumulate in the kidney, a previously unidentified process. |
27 August 2006 |
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A team of researchers from Washington University School of Medicine in St. Louis, the Mayo Clinic in Rochester, Minn., the Harvard School of Public Health and several other clinical centers around the United States has found that treating depression and social isolation in recent heart attack patients does not reduce the risk of death or second heart attack. |
27 August 2006 |
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A team of researchers from Washington University School of Medicine in St. Louis, the Mayo Clinic in Rochester, Minn., the Harvard School of Public Health and several other clinical centers around the United States has found that treating depression and social isolation in recent heart attack patients does not reduce the risk of death or second heart attack. |
26 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis have imaged the activity of an important component of the cell’s garbage-disposal system in living cells and in whole animals. Defects in the component, known as a proteasome, are associated with cancer, neurodegenerative diseases and other disorders. |
26 August 2006 |
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Scientists at the Veterans Affairs Hospital and Washington University School of Medicine in St. Louis are developing a gel-like material that eventually could be used to replace diseased and aging lenses in the eyes of patients with cataracts. The material also might eventually mean the end of bifocals and contact lenses for millions of people who suffer from presbyopia, literally 'old vision', a condition that makes it difficult for people over 40 to read without magnification. |
26 August 2006 |
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When researchers at Washington University School of Medicine in St. Louis transplanted early embryonic pancreatic tissue into the abdomens of adult rats with type I diabetes, the animals developed organs that produced insulin and controlled blood-sugar levels. The animals were cured of their diabetes for the duration of the experiment, which lasted 15 weeks. |
25 August 2006 |
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Steroids called glucocorticoids are critical for treating diseases such as asthma, arthritis and pain syndromes, but they also can trigger diabetes and hypertension. Research at Washington University School of Medicine in St. Louis now shows why these commonly used drugs have such dangerous side effects. |
25 August 2006 |
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Cooper pioneered lung-volume reduction surgery in 1993, in which surgeons remove heavily damaged portions of lungs in patients with severe emphysema. Results from the National Emphysema Treatment Trial, conducted independently of Washington University, will be presented May 20 at the American Thoracic Society’s International Conference in Seattle. |
25 August 2006 |
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Washington University Physicians at Barnes-Jewish Hospital in St. Louis are testing an investigational treatment for cervical disc disease that involves replacing a diseased spinal disc in the neck with an artificial one. |
24 August 2006 |
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A drug used to treat bone loss associated with diseases such as osteoporosis has caused a child to develop an unhealthy, dense skeleton characteristic of a condition called osteopetrosis, or marble bone disease. |
24 August 2006 |
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By taking advantage of techniques developed in the search for Alzheimer’s treatments, a team of researchers has discovered that a molecule called Notch is essential for the development of critical kidney cells. The study, published online and in the journal Development, provides key information about kidney development that could have implications for tissue regeneration. |
24 August 2006 |
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In one of the first studies to track driving performance over time in older adults, researchers at Washington University in St. Louis found that driving abilities predictably worsen in individuals with early Alzheimer’s disease and, to a lesser extent, in older adults without dementia. |
23 August 2006 |
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Some people with diabetes struggle with ulcers forming on the bottom of their feet; worse yet, many of these ulcers come back after treatment. A study at Washington University School of Medicine in St. Louis demonstrates that a surgical procedure to lengthen the Achilles tendons of patients with diabetes significantly reduces the risk of ulcer recurrence. |
23 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis have found that terminally ill children with cancer who have neuropathic pain require more opioids during the final days of life than those without neuropathic pain. |
23 August 2006 |
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“Loss of balance is a significant problem in the elderly because it can lead to dangerous falls and injuries,” says one of the study’s principal investigators, David M. Ornitz, M.D., Ph.D., professor of molecular biology and pharmacology at the School of Medicine. “Loss of balance also is a problem for astronauts following exposure to zero gravity. Now that we’ve discovered this new gene, we can begin to understand the mechanisms that allow the body to sense gravity and maintain balance.” |
22 August 2006 |
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Studying women with histories of clinical depression, investigators at Washington University School of Medicine in St. Louis found that the use of antidepressant drugs appears to protect a key brain structure often damaged by depression. |
22 August 2006 |
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A team led by researchers at Washington University School of Medicine in St. Louis, in collaboration with researchers at Eli Lilly and Co. in Indianapolis, have developed a new technique that, for the first time, provides a way to dynamically study proteins known to be related to Alzheimer’s disease in the fluid between brain cells, called interstitial fluid. |
22 August 2006 |
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An international team of scientists led by researchers at Washington University School of Medicine in St. Louis have found that the enzyme largely responsible for the development of Alzheimer's disease may work in a different way than previously thought. |
21 August 2006 |
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Mice missing a gene called Lmx1b do not produce the important brain chemical serotonin, according to research at Washington University School of Medicine in St. Louis. This is the first evidence that one gene controls development of all cells that produce serotonin in the central nervous system, marking significant progress in understanding this critical nervous system pathway. |
21 August 2006 |
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In the first multicenter trial to look at the high-fat, low-carbohydrate Atkins’ diet, researchers have found that at three and six months, the Atkins’ diet produces significantly greater weight loss than a conventional low-fat, high-carbohydrate diet. |
21 August 2006 |
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Children, adolescents and adults use their brains differently during a simple reading task, according to research at Washington University School of Medicine in St. Louis. Using functional magnetic resonance imaging, the team identified 17 brain regions that distinguish the three age groups. |
20 August 2006 |
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Liposuction is no substitute for dieting when it comes to preventing diabetes, hypertension and heart disease, according to researchers at Washington University School of Medicine in St. Louis. |
20 August 2006 |
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A national team of investigators led by psychiatric geneticists at Washington University School of Medicine in St. Louis has identified a gene that appears to be linked to both alcoholism and depression. |
20 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis are seeking women who have had two or more unexplained first trimester miscarriages to evaluate an experimental treatment to help women carry babies to term. |
19 August 2006 |
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Growing new organs to take the place of damaged or diseased ones is moving from science fiction to reality, according to researchers at Washington University School of Medicine in St. Louis. |
19 August 2006 |
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Investigators at Washington University School of Medicine in St. Louis have found that stimulating the brain's subthalamic nucleus to control motor symptoms of Parkinson's disease has an unintended consequence: It interferes with cognitive function. When given cognitive tests, patients performed better when their stimulators were turned off than when they were turned on. |
19 August 2006 |
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Ophthalmology researchers at Washington University School of Medicine in St. Louis have identified a key risk factor for the development of cataracts. For the first time, they have demonstrated an association between loss of gel in the eye's vitreous body, the gel that lies between the back of the lens and the retina, and the formation of nuclear cataracts, the most common type of age-related cataracts. |
18 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis will head an ambitious study of people who live exceptionally long and healthy lives to identify the factors that account for their longevity. |
18 August 2006 |
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Removal of an immune system signaling protein prevents the development of a lupus-like condition in mice, researchers at Washington University School of Medicine in St. Louis and the National Institutes of Health have found. |
18 August 2006 |
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Scientists working to develop a vaccine for the bacterium Helicobacter pylori, the primary cause of ulcers and a contributor to stomach cancers, have uncovered new intricacies in the way the bacterium sticks to the lining of the human stomach. |
17 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis and the University of Pennsylvania have found an immune system cell can 'remember' a parasite's attack and help the body mount a more effective defense against subsequent invasions by the same parasite. |
17 August 2006 |
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An unpleasant postoperative procedure for thyroid cancer patients who have had their thyroid glands surgically removed may be unnecessary for most patients, according to Washington University researchers at Siteman Cancer Center and Barnes-Jewish Hospital in St. Louis. |
17 August 2006 |
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A possibly important ally of the immune system that can help with the tricky task of separating friend from foe has been identified by scientists at Washington University School of Medicine in St. Louis. |
16 August 2006 |
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In a finding that may one day help researchers better understand age-related memory and hearing loss, scientists have shown that two key nervous system proteins interact in a manner that helps regulate the transmission of signals in the nervous system. |
16 August 2006 |
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Radiologists at Washington University School of Medicine in St. Louis have developed a first-of-its-kind noninvasive imaging technique that allows them to watch two proteins interacting in live animals. |
16 August 2006 |
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A protein linked to increased lifespan in yeast and worms also can delay the degeneration of ailing nerve cell branches, according to researchers at Washington University School of Medicine in St. Louis. |
15 August 2006 |
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A controversial theory about how diabetes causes extensive tissue damage will appear in the November issue of Diabetes. At stake in the heated debate over the theory are researchers' efforts to find new ways to reduce loss of vision, kidney failure, heart damage and other side effects of diabetes. |
15 August 2006 |
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Requiring hospital workers and patient families to wear protective gowns when they visit patients with a drug-resistant bacteria provides infection control benefits that significantly outweigh gown costs, according to a new study led by Washington University School of Medicine in St. Louis. |
15 August 2006 |
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Getting treated for a common type of cancer just became easier: An international team of surgeons including two at Washington University School of Medicine in St. Louis has determined that minimally invasive surgery is as safe and effective as standard open surgery for most patients with cancer confined to the colon. |
14 August 2006 |
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The microorganisms that normally live in the gut can increase body fat, say researchers at Washington University School of Medicine in St. Louis. They found that gut microbes can open the 'gates' fat uses to enter the body's fat cells. |
14 August 2006 |
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Millions of people with severe tinnitus currently have little hope for quick relief from the unrelenting ringing or buzzing noises the disorder produces. But scientists at Washington University School of Medicine in St. Louis suspect a drug already approved for seizure disorders and chronic nerve pain also can help silence the noises that plague tinnitus patients. |
14 August 2006 |
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Nerves talk to each other using chemicals called neurotransmitters. One of those 'communication chemicals,' aptly named gamma amino butyric acid, shows up in unusually high amounts in some aggressive tumors, according to a new study from Washington University School of Medicine in St. Louis. |
14 August 2006 |
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If a woman goes into labor before her baby is full term, her obstetrician must make a crucial recommendation: delay labor or allow it to continue. Delivering the baby prematurely may increase the baby's risk of suffering from neonatal respiratory distress syndrome, a potentially fatal condition. |
13 August 2006 |
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Scientists at Washington University School of Medicine in St. Louis have become the first to successfully grow a norovirus in the lab. In humans, noroviruses are a highly contagious source of diarrhea, vomiting and other stomach upset that made headlines two years ago after a series of repeated outbreaks on cruise ships. These viruses are a major cause of human disease worldwide. |
13 August 2006 |
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The first detailed analysis of the chicken genome has identified a chicken counterpart to an important human immune system protein, revised scientists' assessment of the chicken's sense of smell, and suggested that the chicken, long used to study gene activity in the earliest stages of life, may provide a good model for studying changes in DNA linked to aging and death. |
12 August 2006 |
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Progress toward development of a breast cancer vaccine has been reported by researchers at Washington University School of Medicine and the Siteman Cancer Center in St. Louis. |
12 August 2006 |
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A recently developed mouse model of brain tumors common in the genetic disorder neurofibromatosis 1 successfully mimics the human condition and provides unique insight into tumor development, diagnosis and treatment, according to researchers at Washington University School of Medicine in St. Louis. |
12 August 2006 |
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Researchers knew that prions, the misfolded proteins that cause mad cow disease and other brain disorders, were killing off a class of important brain cells in a transgenic mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick. |
11 August 2006 |
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Child psychiatry researchers at Washington University School of Medicine in St. Louis are investigating the effectiveness of several therapies for children with bipolar disorder, also known as manic depressive illness. |
11 August 2006 |
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An improved stem cell transplant regimen that is well-tolerated and has a high success rate has been developed by researchers at Washington University School of Medicine in St. Louis. The procedure holds promise for treatment of blood and bone marrow disorders, immune dysfunction and certain metabolic disorders. |
11 August 2006 |
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Drugs used to treat the tumors common in people with a disorder called neurofibromatosis 1 rarely work, and scientists now know why. The chemotherapy drugs target a group of related proteins, call RAS proteins, which are thought to be responsible for these tumors. But researchers at Washington University School of Medicine in St. Louis found that the disease affects only one member of the protein family, and it happens to be the one form of RAS that does not respond well to these particular treatments. |
10 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis have identified a previously unsuspected response by mouse heart muscle cells to fasting conditions: the cells' power generators, the mitochondria, appear to remodel and consume extra internal walls or membranes in an effort to supply energy to the rest of the cell. |
10 August 2006 |
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The bacterium that causes ulcers and contributes to stomach cancers uses a clever interaction between two genes to randomly tighten and loosen its grip on the stomach, according to a study by researchers at Washington University School of Medicine in St. Louis and Umeå University in Sweden. |
09 August 2006 |
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Research suggests some instant teas may contain excessive levels of fluoride.
Instant tea, one of the most popular drinks in the United States, may be a source of harmful levels of fluoride, researchers at Washington University School of Medicine in St. Louis report. The researchers found that some regular strength preparations contain as much as 6.5 parts per million (ppm) of fluoride, well over the 4 ppm maximum allowed in drinking water by the Environmental Protection Agency and 2.4 ppm permitted in bottled water and beverages by the Food and Drug Administration. |
09 August 2006 |
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Scientists studying a common childhood brain tumor have uncovered a pleasant surprise: evidence that the tumors may be vulnerable to a class of drugs that has been in use for years. |
09 August 2006 |
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Researchers at Washington University School of Medicine in St. Louis are seeking volunteers to participate in a study to determine if botulinum toxin injections can help heal diabetic foot ulcers. |
08 August 2006 |
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A class of anti-seizure medications slows the rate of aging in roundworms, according to researchers at Washington University School of Medicine in St. Louis. When exposed to drugs used to treat epilepsy in humans, worms lived longer and retained youthful functions longer than normal. |
08 August 2006 |
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In a six-month study of elderly people, researchers at Washington University School of Medicine in St. Louis found that the hormone dehydroepiandrosterone significantly reduced abdominal fat and improved insulin action. This finding suggests that DHEA may be able to counter the increase in abdominal fat and accompanying increased risk for diabetes that very often occurs as we grow older. |
08 August 2006 |
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In the midst of the growing epidemic of obesity, a group of researchers at Washington University School of Medicine in St. Louis has dived into the human gene pool to look for solutions. The group recently identified genetic variations unique to obese men and are now embarking on a wider search to find additional genes linked to obesity. |
07 August 2006 |
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Specially designed nanoparticles can reveal tiny cancerous tumors that are invisible by ordinary means of detection, according to a study by researchers at Washington University School of Medicine in St. Louis. |
07 August 2006 |
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Washington University researchers identified the instructions for building a potentially important protein in the genome of the SARS virus. Shown here are a diagram of the protein's structure and an image from an experiment that proved SARS makes the protein in infected cells. |
07 August 2006 |
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In a new study published in the American Journal of Ophthalmology, researchers at Washington University School of Medicine in St. Louis report the culprit may be oxygen. |
06 August 2006 |
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In the near future, an alarm sounding outside the operating room door may have surgeons reaching for their pens. That's because a new device has been designed to alert the surgical team if a patient's incision site hasn't been marked. Invented by a physician at Washington University School of Medicine in St. Louis, the device, a wristband that enforces surgical-site marking, should help eliminate wrong-site surgeries. |
06 August 2006 |
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Scientists have found a new role for a previously identified enzyme that may make it a target for anti-inflammatory treatments. |
06 August 2006 |
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For years, two schools of thought have dominated neurobiologists' theories about how early nerve cells develop specialties that allow the assembly of a mature brain. |
05 August 2006 |
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You win some, you lose some. A protein that protects the body from tissue damage also increases the risk of tumors, according to a study conducted at Washington University School of Medicine in St. Louis. Moderate reduction of the protein level protects against tumor formation but increases susceptibility to tissue injury. |
05 August 2006 |
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Expectant mothers at risk of premature birth may want to consider drinking pomegranate juice to help their babies resist brain injuries from low oxygen and reduced blood flow, a new mouse study from Washington University School of Medicine in St. Louis suggests. |
05 August 2006 |
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Opening the possibility of new therapies for type 2 diabetes, researchers at Washington University School of Medicine in St. Louis have found that a protein called Sirt1 enhances the secretion of insulin in mice and allows them to better control blood glucose levels. |
04 August 2006 |
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Newborn mice and dogs with hemophilia A were restored to normal health through gene therapy developed by researchers at Washington University School of Medicine in St. Louis. The technique introduced into the animals' cells a gene that makes clotting factor VIII, a protein missing because of a genetic defect. |
04 August 2006 |
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The researchers are learning how autism is inherited, and to identify genetic factors, they're studying families and looking for traits that normally aren't considered autistic but have connections to autism risk. Several studies have demonstrated that autism has a strong genetic component. If one child in a family is autistic, there's about a 10 percent chance that a sibling also will have autism. |
03 August 2006 |
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Most parents would never consider letting their 6-year-old child ride on the back of a motorcycle, yet many adults don't think twice about letting kids ride all-terrain vehicles. |
03 August 2006 |
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Sequencing the human genome was not the end of the Human Genome Project, says Richard Wilson.Comparing the human genome to the chimpanzee genome has allowed scientists to identify changes in the human genetic code that were so advantageous that they rapidly became the norm throughout humanity. |
03 August 2006 |
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College students talk about the 'Freshman 15.' That's the typical number of credit hours a full-time student takes during a semester. Some also claim it's the number of pounds students gain eating dorm food and studying all night. |
02 August 2006 |
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Scientists have uncovered a new method the immune system uses to label foreign invaders as targets to be attacked. Researchers showed that the immune system can brand foreign proteins by chemically modifying their structure, and that these modifications increased the chances that cells known as lymphocytes would recognize the trespassers and attack them. |
02 August 2006 |
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A pilot study comparing the results of treatment for rheumatoid arthritis in African-Americans and Caucasians has revealed that African-Americans are more likely to suffer pain and disability from the disorder. |
02 August 2006 |
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A promising new anti-cancer drug will be tested against several forms of thyroid cancer in a newly opened clinical trial at the Siteman Cancer Center of Washington University School of Medicine in St. Louis and Barnes-Jewish Hospital. Previous research showed that the compound, called 17AAG, has the unusual ability to simultaneously affect multiple proteins implicated in human cancers. |
01 August 2006 |
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Like throwing oil on a fire or prescribing a high cholesterol diet for heart patients, gastroenterologists traditionally have believed that it would not be a good idea to stoke up the body's immune system to treat Crohn's disease. Most treatments for Crohn's, an autoimmune disorder, are geared to suppress the immune response, but a new study demonstrates that stimulating innate immunity also is effective at improving symptoms in many patients with the intestinal disorder. |
01 August 2006 |
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A protein that helps the ends of growing nerve cells push forward is also involved in guidance of the nerve branches, according to a study by researchers at Washington University School of Medicine in St. Louis. |
01 August 2006 |
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Neuroscientists at Washington University School of Medicine in St. Louis have assembled a first-of-its kind atlas of the folds of the cerebral cortex, the wrinkled surface layer of the brain credited with many of the higher cognitive functions that make us human. The atlas, known as the Population-Average, Landmark and Surface-based Atlas, links brain functions to the various peaks and valleys of the cortex. |
31 July 2006 |
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The first direct analysis of the interactions between two brain networks that govern visual attention may help researchers working to develop treatments for stroke patients with a condition known as spatial neglect. |
31 July 2006 |
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Scientists have discovered that a group of important immune system cells has a surprising resemblance to cinematic British superspy James Bond: the cells receive a 'license' that allows them to unleash their most potent attacks on enemies. |
31 July 2006 |
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Neuroscientists at Washington University School of Medicine in St. Louis have assembled a first-of-its kind atlas of the folds of the cerebral cortex, the wrinkled surface layer of the brain credited with many of the higher cognitive functions that make us human. The atlas, known as the Population-Average, Landmark and Surface-based Atlas, links brain functions to the various peaks and valleys of the cortex. |
30 July 2006 |
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A combination of brain scanning with a new imaging agent and cerebrospinal fluid analysis has left neuroscientists encouraged that they may finally be moving toward techniques for diagnosing Alzheimer's disease before its clinical symptoms become apparent. |
30 July 2006 |
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Contrary to psychologists' expectations, breast cancer survivors don't experience an extended emotional crisis after their treatment regimens end, according to a new study by researchers at Washington University School of Medicine in St. Louis. The study appears in the December issue of Supportive Care in Cancer. |
30 July 2006 |
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As the New Year begins, millions of people are resolving to exercise more. A team of researchers at Washington University School of Medicine in St. Louis hopes that similar lifestyle changes will help HIV-positive people avoid metabolic and cardiovascular problems associated with HIV and anti-HIV drugs. |
29 July 2006 |
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By peering into the minds of volunteers preparing to play a brief visual game, neuroscientists at Washington University School of Medicine in St. Louis have found they can predict whether the volunteers will succeed or fail at the game. |
29 July 2006 |
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A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious process at a later point. |
29 July 2006 |
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A study of patients who have difficulty paying attention to the left side of their environment has provided some of the first direct evidence that brain injury can cause detrimental functional changes in brain regions far from the site of the actual injury. |
28 July 2006 |
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Child psychiatry researchers at Washington University School of Medicine in St. Louis have identified a small group of preschoolers who appear to suffer from bipolar disorder, also known as manic-depressive illness. The findings, presented this fall at the annual meeting of the American Academy of Child and Adolescent Psychiatry, highlight symptoms that distinguish bipolar disorder from other mental health problems in very young children. |
28 July 2006 |
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A team of researchers, led by investigators at Washington University School of Medicine in St. Louis, has found that a gene variant for a bitter-taste receptor on the tongue is associated with an increased risk for alcohol dependence. |
28 July 2006 |
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An international team of researchers, led by investigators at Washington University School of Medicine in St. Louis, are zeroing in on a gene that increases risk for Alzheimer's disease. They have identified a region of chromosome 10 that appears to be involved in risk for the disease that currently affects an estimated 4.5 million Americans. |
27 July 2006 |
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To remain healthy, all cells must quickly mend any breaks that arise in their DNA strands. But cancer cells are particularly dependent on a process called homologous recombination to repair DNA and stay alive. |
27 July 2006 |
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The researchers discovered a rare change in the DNA of two eastern Missouri families with a history of a condition called X-linked recessive idiopathic hypoparathyroidism: a portion of the X chromosome, a human sex chromosome, has been removed and replaced by a copy of a much larger section of genetic material from chromosome 2. Alterations of such large regions of genetic code that stably pass from one generation to the next are generally rare and have never before been observed in the human X chromosome. |
27 July 2006 |
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Investigators at Washington University School of Medicine in St. Louis have found that cells making up a non-visual system in the eye are in place and functioning long before the rods and cones that process light into vision. The discovery should help scientists learn more about the eye's non-visual functions such as the synchronization of the body's internal, circadian clock, the pupil's responses to light and light-regulated release of hormones. |
26 July 2006 |
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A molecule that has long been an obstacle to cancer chemotherapy and drug treatments for brain disorders may soon become an ally in the fight against Alzheimer's disease, according to researchers at Washington University School of Medicine in St. Louis and the University of Rochester. |
26 July 2006 |
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Elderly patients taking the commonly prescribed blood thinner warfarin experience an increased risk for osteoporosis-linked bone fractures, according to a study at Washington University School of Medicine in St. Louis. The results suggest physicians should carefully monitor the bone health of patients placed on the medication and that their patients should take steps to decrease the risk of osteoporosis. |
26 July 2006 |
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Current treatments for asthma and chronic bronchitis aren't able to address the ultimate source of the problem, they can only alleviate symptoms. But researchers at Washington University School of Medicine in St. Louis have gone to the root of these disorders and found a two-drug treatment that could potentially restore patients' troubled airways to healthy function. |
25 July 2006 |
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Increased communication between brain cells increases levels of amyloid beta, the key ingredient in Alzheimer's brain plaques, scientists at Washington University School of Medicine in St. Louis have found. |
25 July 2006 |
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Scientists have known for decades that female lab mice or their pheromones cause male lab mice to make ultrasonic vocalizations. But a new paper from researchers at Washington University School of Medicine in St. Louis establishes for the first time that the utterances of the male mice are songs. |
25 July 2006 |
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Researchers studying a mouse model of neurofibromatosis 1, a genetic condition that causes childhood brain tumors, have found their second new drug target in a year, a protein called methionine aminopeptidase-2. |
24 July 2006 |
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Increased communication between brain cells increases levels of amyloid beta, the key ingredient in Alzheimer's brain plaques, scientists at Washington University School of Medicine in St. Louis have found. |
24 July 2006 |
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Defeating cancerous tumors by attacking healthy cells seems like an unusual strategy, but researchers at Washington University School of Medicine in St. Louis have shown the strategy to be effective against leukemia/lymphoma in mice. |
24 July 2006 |
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The largest detailed, prospective clinical study of the mental side effects of a potent anti-AIDS drug, efavirenz, has revealed that the anxiety, dizziness, 'funny feelings' and vivid dreams triggered by the drug fade away within a month, possibly clearing the way for more widespread use. |
23 July 2006 |
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After preliminary success using artificial bone to replace degenerative spinal disks in the neck and lower back, neurosurgeons at Washington University School of Medicine and Barnes-Jewish Hospital are preparing a study to formally compare the performance of the synthetic material against that of real bone. |
23 July 2006 |
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A team of researchers at Washington University School of Medicine in St. Louis is studying how fatty liver disease affects sugar and fat metabolism in overweight adolescents and how losing weight affects the condition. In the last 30 years, the number of overweight children has doubled in the United States, and overweight children are at increased risk for the problem. |
23 July 2006 |
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With commonly available treatment strategies, 90 percent of women with recurrent cervical cancer die within five years. So physicians are understandably eager to uncover more effective drug therapies, and researchers at Washington University School of Medicine in St. Louis have now obtained encouraging results by combining a traditional cell-killing agent with Avastin, a recently developed inhibitor of blood-vessel growth. |
22 July 2006 |
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Scientists have identified a receptor protein that helps the fruit fly know when to start and shut down its day, a step that should help them learn more about internal clocks in higher organisms such as humans. |
22 July 2006 |
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Can eating a low-calorie yet nutritionally balanced diet extend human life as it does in rodents? Preliminary research suggests it might, so researchers at Washington University School of Medicine in St. Louis are launching a long-term study to find out. |
22 July 2006 |
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Failing hearts develop interference in their communication channels, according to research conducted at Washington University School of Medicine in St. Louis. The problem involves a subtle change in the pores that connect heart muscle cells. When the scientists duplicated this change in mice, the mice became susceptible to ventricular tachycardia, a dangerous heart rhythm disorder that can lead to sudden cardiac death. |
21 July 2006 |
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The U.S. Food and Drug Administration has approved a surgical procedure that helps resurface worn out hip joints rather than completely replacing them, and the first approved procedure in the U.S. was performed by a Washington University orthopaedic surgeon at Barnes-Jewish Hospital in St. Louis. |
21 July 2006 |
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Diabetes researchers hoping to enlist the help of a protein targeted by cancer therapies have gained an important new insight into how the protein, known as mTOR, works in the pancreas. |
21 July 2006 |
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In many cases of advanced emphysema, a chronic, progressive lung condition that interferes with breathing, reducing the size of the lungs by surgically removing lobes from both sides has been shown to improve both survival and quality of life. But some emphysema patients can't tolerate this bilateral operation. |
20 July 2006 |
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A team of researchers at Washington University School of Medicine in St. Louis has found that using lobes of lungs from living donors improves the chances of short-term survival for children who require a second lung transplant. |
20 July 2006 |
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Children between the ages of 6 and 17 years old with moderate-to-severe asthma may be eligible for a study at Washington University School of Medicine to evaluate whether two medications can reduce the amount of inhaled steroids needed to control asthma. |
20 July 2006 |
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Scientists have completed an extensive study of more than 3,000 patients who received a promising anti-inflammatory drug, natalizumab, that was linked to three cases of a serious brain infection in large clinical trials halted. |
19 July 2006 |
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The newest concept for treating coronary artery disease is to induce hearts to grow their own new blood vessels to bypass damaged tissue or clogged arteries. Unfortunately, clinical trials of two important blood-vessel growth factors, fibroblast growth factor 2 and vascular endothelial growth factor have not produced stellar results. |
19 July 2006 |
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Researchers at Washington University School of Medicine in St. Louis have found that obese elderly people can improve their physical function and lessen frailty by losing weight and exercising. |
19 July 2006 |
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A team of researchers at Washington University School of Medicine in St. Louis found that an antidepressant medication may reduce the risk of recurrent depression and increase the length of time between depressive episodes in patients with diabetes. |
18 July 2006 |
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An epilepsy drug that has been on the market for decades can ease the symptoms of adult sufferers with a genetic disorder that seriously weakens muscles. Scientists at Washington University School of Medicine in St. Louis retrospectively reviewed results from off-label use of the drug valproate to treat seven adult spinal muscular atrophy patients. |
18 July 2006 |
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Clinicians who care for patients infected with HIV are testing a new set of experimental treatments that may eliminate the hidden copies of the virus that previously have made a cure unattainable. |
18 July 2006 |
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Science is now poised to answer an important and longstanding question about the origins of Alzheimer's disease: Do Alzheimer's patients have high levels of a brain protein because they make too much of it or because they can't clear it from their brains quickly enough? |
17 July 2006 |
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Preliminary studies have shown that almost 50 percent of people who experience uncontrolled asthma symptoms have a chronic airway infection that they aren't aware of. Now researchers at Washington University School of Medicine in St. Louis are testing to see if treatment with an antibiotic will ease asthma symptoms in these patients. |
17 July 2006 |
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A pill containing plant substances called sterols can help lower cholesterol, according to researchers at Washington University School of Medicine in St. Louis.
The researchers studied patients who already were eating a heart-healthy diet and taking statin drugs to control cholesterol. The addition of plant sterols helped further lower total cholesterol and contributed to a nearly 10 percent reduction in low-density lipoprotein cholesterol, the so-called 'bad' cholesterol. Results of the study were published in the American Journal of Cardiology. |
17 July 2006 |
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Scientists have identified the first clue that welding might trigger the early onset of Parkinson’s disease. A research team led by neurologist Brad A. Racette, M.D., found that 15 professional welders developed typical clinical and neurological signs of the disease an average of 15 years earlier than the general population. The study is featured in the January issue of the journal Neurology with an accompanying editorial. |
22 January 2006 |
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Using a technique pioneered by Washington University in St. Louis chemist Karen Wooley, Ph.D., scientists have developed a novel way to make discrete carbon nanoparticles for electrical components used in industry and research. The method uses polyacrylonitrile (PAN) as a nanoparticle precursor and is relatively low cost, simple and potentially scalable to commercial production levels. It provides significant advantages over existing technologies to make well-defined nanostructured carbons. |
10 May 2004 |
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A close relative of a common little-understood human virus that causes an estimated 23 million episodes of intestinal illness, 50,000 hospitalizations and 300 deaths each year has been discovered in mice. The finding by scientists at Washington University School of Medicine in St. Louis is reported in the March 7 issue of the journal Science. |
06 March 2003 |
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Genetic differences that prevent tiny blood vessels from relaxing may be one reason why some people have high blood pressure, or hypertension, according to research led by scientists at Washington University School of Medicine in St. Louis. The findings are published in the February issue of the Journal of Clinical Investigation. |
15 February 2003 |
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Genetic differences that prevent tiny blood vessels from relaxing may be one reason why some people have high blood pressure, or hypertension, according to research led by scientists at Washington University School of Medicine in St. Louis. The findings are published in the February issue of the Journal of Clinical Investigation. |
15 February 2003 |
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Research at Washington University School of Medicine in St. Louis reveals that a unique combination of genes inherited less than 10,000 years ago allows the parasite responsible for toxoplasmosis to infect virtually all warm-blooded animals. |
16 January 2003 |
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Herpes viruses are notorious for their ability to hide from the immune system and establish lifelong infections. Researchers at Washington University School of Medicine in St. Louis have discovered how one mouse herpes virus escapes detection. The study appears in the January issue of the journal Immunity. |
14 January 2003 |
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Headbands intended to protect soccer players from head injuries are effective only at high speeds, according to research at Washington University in St. Louis. The team found that all four brands of commercial headbands eased the impact of a soccer ball at the highest speeds and pressures tested, but failed to reduce the force at slower speeds. |
10 January 2003 |
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Investigators at Washington University School of Medicine in St. Louis have demonstrated that a particular protein is important for the eye’s pupil to respond to light. The discovery may help scientists learn more about the eye’s role in non-visual functions such as the synchronization of the body’s internal, circadian clock. |
09 January 2003 |
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Headbands intended to protect soccer players from head injuries are effective only at high speeds, according to research at Washington University in St. Louis. The team found that all four brands of commercial headbands eased the impact of a soccer ball at the highest speeds and pressures tested, but failed to reduce the force at slower speeds. |
02 January 2003 |
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Researchers at Washington University School of Medicine in St. Louis have discovered a possible new mechanism for regulating large groups of genes. While conducting yeast research on a potential new anticancer drug, the team identified a mechanism that enables the genome to silence large numbers of genes simultaneously, rather than each gene individually. |
19 December 2002 |
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Washington University School of Medicine in St. Louis is participating in a national study to determine which medication should be used first to treat children with mild asthma. |
19 November 2002 |
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A preliminary study reports that enhancing the body’s innate immunity can improve symptoms of Crohn’s disease in 80 percent of patients with moderate to severe forms of the debilitating, inflammatory gastrointestinal disorder. |
07 November 2002 |
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A new technique enables doctors to directly examine the lining of milk ducts in the breast for early signs of cancer and other abnormalities, according to research at Washington University School of Medicine in St. Louis. The researchers used the technique, known as ductoscopy, to detect breast abnormalities in women with a condition called pathologic nipple discharge. |
04 November 2002 |
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A national clinical trial with 80 Parkinson’s disease patients has found that high dosages of a naturally occurring compound, coenzyme Q10, may slow patients’ progressive clinical deterioration by as much as 44 percent. The greatest benefit was seen in everyday activities such as feeding, dressing, bathing and walking. |
14 October 2002 |
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A study by researchers at Washington University School of Medicine in St. Louis has found that the number of months between recurrences of superficial bladder cancer progressively shortens with each recurrence. The study also identified two proteins in tumor cells that may help predict the risk of a first or second recurrence. The findings will be published online Sept. 5 in the journal Cancer and in the Sept. 15 print edition. |
05 September 2002 |
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Herpes viruses enter the body and hide away in cells, often re-emerging later to cause illnesses such as shingles, genital herpes and cancer. How these viruses evade the immune system remains poorly understood, but researchers at Washington University School of Medicine in St. Louis discovered that a mouse herpes virus uses molecules that mimic a cell’s own proteins to help thwart an immune attack. |
20 August 2002 |
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Though previous evidence points to the contrary, scientists have discovered that the protein known as fibroblast growth factor 14 may not actually behave like a growth factor. The research suggests that FGF14 is instead involved in transmitting signals from one nerve cell to another and may help regulate walking and other movements. The protein could, therefore, be linked to movement disorders such as Parkinson’s and Huntington’s diseases. |
11 July 2002 |
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Radiation from cell phones doesn’t appear to cause cancer in rats, according to a study by researchers at Washington University School of Medicine in St. Louis. The research team exposed rats to the two most common types of cell phone radiation for four hours a day, five days a week for two years. |
25 June 2002 |
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Memory and pain are not inextricably linked, according to research at Washington University School of Medicine in St. Louis. The results may help scientists develop medications that treat acute or chronic pain without compromising a patient’s ability to think. |
06 June 2002 |
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An international study led by researchers at Washington University School of Medicine in St. Louis has found that a drug normally used to treat acute rejection of transplanted kidneys also can dramatically prevent rejection when administered during surgery. |
29 April 2002 |
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Researchers at Washington University School of Medicine in St. Louis have found a possible marker for women at risk for recurrent endometrial cancer, a disease that is usually fatal. The study also suggests that African-American women may be at higher risk for recurrence of this malignancy. The findings are published in the June 1 issue of the journal Cancer. |
29 April 2002 |
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Scientists at Washington University School of Medicine in St. Louis have for the first time identified a chemical messenger that regulates bone development in the growing embryo. |
02 April 2002 |
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Excess abdominal fat increases the risk of hypertension, abnormal blood cholesterol, type 2 diabetes and heart disease. Researchers at Washington University School of Medicine in St. Louis want to learn whether removing fat from the mid-section might help reduce the risk of developing these diseases. |
26 March 2002 |
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Researchers have for the first time used a blood test to identify Alzheimer’s-type changes in living mice. The test, developed by researchers at Washington University School of Medicine in St. Louis and Eli Lilly and Company, predicts the amount of amyloid plaque in an animal’s brain, a hallmark of Alzheimer’s disease. To date, the only way to definitively diagnose this disease in humans is by examining a person’s brain after death. |
21 March 2002 |
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In the first national effort of its kind, researchers around the country are collaborating to study the body’s response to critical illness and traumatic injuries such as motor vehicle accidents, gunshot wounds and burns. |
18 February 2002 |
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A tiny change in the cells of patients with neurofibromatosis seems to contribute to formation of aggressive tumors and could help explain why the disease, which predisposes patients to develop tumors, affects people in different ways. |
07 January 2002 |
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When people with lung cancer are treated with radiation therapy, the size of their tumor may be the best predictor of the treatment’s success, rather than how far the tumor has spread within the lung.This finding by researchers at Washington University School of Medicine in St. Louis is published in the January issue of the International Journal of Radiation Oncology, Biology and Physics. |
04 January 2002 |
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Researchers at Washington University School of Medicine in St. Louis and The Rotman Research Institute at Baycrest Centre for Geriatric Care in Toronto have joined to expand the understanding of brain injury and its impact on everyday life. |
04 January 2002 |
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Pediatric researchers at Washington University School of Medicine in St. Louis are collaborating in a new national study to determine how to identify the best asthma medications for particular patients. Children with mild to moderate asthma may be eligible to participate in the study. This research is the first of its kind to examine how individual differences affect the body’s response to asthma medications. |
03 January 2002 |
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Using an antibody that specifically identifies the active form of Notch, Kopan’s group observed that the protein is extremely active in the kidney at an earlier stage than previously thought. So they teamed up with kidney development expert Jeffrey H. Miner, Ph.D., associate professor of medicine and of cell biology and physiology, to investigate further. First, though, they had to resolve a methodological conundrum: How do you study the effect of Notch in the kidney if animals without Notch die before the kidney begins to form? |
30 November 2001 |
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A team of researchers led by Prof. Irun Cohen of the Weizmann Institute of Science has developed a unique approach for halting the progression of Type I (juvenile or insulin-dependent) diabetes. Cohen and Dr. Dana Elias (then a postdoctoral fellow at the Institute) discovered that injecting mice with a small peptide fragment known as p277 prevents the progression of Type I diabetes. Based on the results of his research, Peptor, a biopharmaceutical company from Rehovot, Israel, developed DiaPep277, an experimental drug designed to prevent or treat Type I diabetes. |
26 November 2001 |
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Brain imaging works well in children, too, according to new research at Washington University School of Medicine in St. Louis. The results are good news both for scientists studying brain development and for pediatric patients with neurological problems, says principal investigator Bradley L. Schlaggar, M.D., Ph.D., instructor of neurology and pediatrics. |
13 November 2001 |
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Neuroscientists at Washington University School of Medicine in St. Louis and Duke University Medical Center in Durham, North Carolina, are launching a study they hope will help clarify the mind/body connection in depressed older people. |
01 November 2001 |
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Scientists at Washington University School of Medicine in St. Louis have mapped and sequenced the genome for a bacterium that is a leading cause of food poisoning worldwide: Salmonella typhimurium. |
24 October 2001 |
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A team of researchers, led by anesthesiologists at Washington University School of Medicine in St. Louis, has found that an investigational drug helps patients recover bowel function more quickly after abdominal surgery, leading to less post-operative illness and quicker discharge from the hospital. |
27 September 2001 |
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Alzheimer’s disease is the most common cause of dementia in older adults and affects about 4.5 million Americans. Affected individuals experience memory difficulties and problems with attention and eventually lose the ability to perform complicated tasks like driving. |
31 July 2001 |
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The study, conducted by researchers at Washington University School of Medicine in St. Louis and Eli Lilly and Company, used an antibody that targets a particular region on the amyloid-beta protein. The amyloid-beta protein accumulates in the brain to form the amyloid plaques, a major feature of Alzheimer’s disease. The study is published in the July 3 issue of the Proceedings of the National Academy of Sciences Early Edition. |
03 July 2001 |
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Scientists have discovered that gamma-secretase inhibitors, the most promising drugs under development for Alzheimer’s disease, also prevent certain immune cells from being produced. These drugs are in the early stages of human testing. |
19 June 2001 |
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Researchers at Washington University School of Medicine in St. Louis have developed a formula to predict the risk of stroke in patients with an irregular heart rhythm called atrial fibrillation. |
13 June 2001 |
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Using this new technique in mice, the team discovered that the relationship between levels of a key molecule involved in Alzheimer’s disease, amyloid-beta, in interstitial fluid and cerebrospinal fluid changes as the disease progresses. Cerebrospinal fluid, the fluid that cushions and surrounds the brain, is a main focus in efforts to diagnose and possibly treat Alzheimer’s disease. |
11 June 2001 |
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A recently discovered protein appears essential for lung development. Mice unable to make a protein called fibroblast growth factor 9 die at birth with underdeveloped lungs, researchers have found. They suggest that Fgf9 controls lung size and shape. |
17 May 2001 |
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Patients with advanced cancer of the nasal passages who receive a combination of chemotherapy and a cutting-edge radiation technique called intensity modulated radiation therapy live longer than patients who receive conventional radiation, according to a new study by Washington University School of Medicine in St. Louis. |
12 April 2001 |
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Researchers have identified a protein that plays an important role in neonatal brain injury. The protein, clusterin, also might contribute to adult brain damage, for example after spinal cord injury and stroke. |
23 February 2001 |
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A multi-center team of researchers has discovered a possible genetic cause of infant lung disease. They found that two patients who developed a potentially fatal form of lung disease within the first months of life both had a mutation of one of the genes responsible for producing pulmonary surfactant, a material in the lungs that keeps them inflated. The study is reported in the Feb. 22 issue of the New England Journal of Medicine. |
22 February 2001 |
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Scientists have obtained further evidence for a revolutionary way of viewing the prevalent respiratory disease, asthma. Combining complementary findings from mice and humans, they propose a modern scheme for the development of the disease. The study is presented in the Feb. 5 issue of Journal of Experimental Medicine. |
22 January 2001 |
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To young children and their parents, a trip to the emergency room for stitches can mean not only the pain of an injury but also anxiety about the procedure. |
07 January 2001 |
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Discovery of the new virus, known as murine norovirus 1, may lead to a better understanding of its disease-causing cousins known as Norwalk viruses, or human noroviruses. HNVs cause 90 percent of epidemic viral gastroenteritis worldwide, including those that sweep through cruise ships, nursing homes and military encampments causing debilitating diarrhea and vomiting. |
23 December 2000 |
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Investigators at Washington University in St. Louis led an international research team that has identified a new genetic risk factor for Alzheimer’s disease. The researchers still are working to isolate the specific gene, but they have isolated the region of DNA that contains it. |
22 December 2000 |
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Researchers at Washington University School of Medicine in St. Louis have imaged language areas of the brain during recovery from stroke. This glimpse into the brain's natural rehabilitation pattern could lead to a better understanding of normal language processes and help optimize stroke therapy. The study is reported in the Dec. 26 issue of the journal Neurology. |
22 December 2000 |
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Blood pressure is the force exerted by the blood against artery walls. Nearly one in four adults in the United States are estimated to have above-normal blood pressure. The condition is most common in African Americans and the elderly. Uncontrolled high blood pressure greatly increases risk for stroke, atherosclerosis, heart attack and kidney failure, and it can aggravate symptoms of diabetes. |
12 December 2000 |
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The team was led by Russell N. Van Gelder, M.D., Ph.D., assistant professor of ophthalmology and visual sciences and of molecular biology and pharmacology. Reporting in the Jan. 10 issue of the journal Science, the researchers say that mice that lack the two main types of photoreceptor cells in the retina, rods and cones, as well as proteins in the retina called cryptochromes, lose about 99 percent of their sensitivity to light. |
11 December 2000 |
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Researchers at Washington University School of Medicine in St. Louis have found that a new technique called constraint-induced movement therapy, or forced-use therapy, allows stroke patients to improve motor functions, even if therapy does not begin until 14 days after their stroke. The results from this pilot study appear in the December issue of the journal Stroke. |
30 November 2000 |
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Social isolation and depression are important risk factors for heart attack and death. About 25 percent of heart attack patients have one of these conditions, contributing to a three- to four-fold increase in their risk of death. The ENRICHD study hoped to change those odds by offering treatment to heart attack patients with depression or low social support. |
28 November 2000 |
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About 200 million people worldwide play soccer, yet there is little research on the neurological dangers of hitting a soccer ball with the head, a common practice called “heading.” |
12 November 2000 |
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Washington University investigators have shown that a weight-loss drug, orlistat, can help prevent obese people from absorbing cholesterol from their food. They present their findings today at the annual scientific meeting of the North American Association for the Study of Obesity in Long Beach, Calif. |
01 November 2000 |
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New study subjects had medically significant obesity, meaning that they weighed at least 20 percent more than their ideal body weight. They began the study an average of about 50 pounds overweight. |
31 October 2000 |
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New genetic research technologies, such as DNA chips, enable scientists to evaluate tissue samples from several patients simultaneously, expressing thousands of genes. However, deciphering the vast amount of information derived, consisting of anything from 100,000 to 1,000,000 genetic 'figures,' requires highly sophisticated data processing tools. |
16 October 2000 |
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Parasite life cycles are complex and thought to develop over long periods with their hosts. This study reveals that parasites sometimes adapt rapidly to new hosts, indicating that host-parasite relationships may not always represent stable, long-term associations. |
12 October 2000 |
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In the Sept. 26 issue of Proceedings of the National Academy of Sciences, they report that some areas of the brain which are involved in looking at pictures and listening to sounds are also involved in remembering them. |
21 September 2000 |
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Using this imaging method, the investigators found that an experimental anticancer drug that inhibits proteasome function does in fact reach effective levels in experimental tumors, and that the drug may become more potent after weeks of use. |
12 September 2000 |
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In addition to their hallmark study published in 1996 in the Journal of Thoracic and Cardiovascular Surgery, which showed that LVRS significantly improves quality of life in patients with severe emphysema, Cooper’s team recently published two reports, one in the Journal of Thoracic and Cardiovascular Surgery and one in the journal Chest, that demonstrate long-term improvements in overall health and quality of life for these individuals. The studies also confirm the validity of several key selection criteria and suggest that patients who require surgery to the upper lobes of the lungs respond better than those who require surgery to the lower portion of the lungs. |
03 September 2000 |
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Theodore Reich, M.D., the Samuel and Mae S. Ludwig Professor of Psychiatry and professor of genetics at Washington University School of Medicine in St. Louis, will help lead an international team of geneticists in a three-year study that will attempt to uncover the genetic basis of depression. |
01 August 2000 |
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Scientists studying how the bladder responds to bacteria that cause urinary tract infections are now closer to understanding why these infections keep coming back.
UTIs afflict one in four American women at some point in their lives, as well as some men. Intense pain, burning and frequent |
