Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Inhibitory systems control the pattern of activity in the cortex

Yale University : 26 August, 2005  (New Product)
Inhibitory systems are essential for controlling the pattern of activity in the cortex, which has important implications for the mechanisms of cortical operation, according to a Yale School of Medicine study in Neuron.
Inhibitory systems are essential for controlling the pattern of activity in the cortex, which has important implications for the mechanisms of cortical operation, according to a Yale School of Medicine study in Neuron.

The findings demonstrate the inhibitory network is central to controlling not only the amplitude, extent and duration of activation of recurrent excitatory cortical networks, but also the precise timing of action potentials, and, thus, network synchronization, said David McCormick, professor of neurobiology and senior author of the study.

There are two cell types in the cortex, excitatory and inhibitory. The cortex has a tendency to make recurrent excitation, and, if not properly controlled by the inhibitory system, this could lead to seizures, as is seen in epilepsy.

'Temporal precision in spike timing is important in cortical function, interactions, and plasticity,' McCormick said. 'We found that, during periods of recurrent network activity, cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.'

McCormick said the spike timing is important for fine perception and may underlie problems in the nervous system and in psychiatric disorders, such as schizophrenia, where the timing problem might cause confusion. These results therefore broaden the influence of the local inhibitory networks in the cortex from one of simple regulation of excitability to one of also controlling cognitive function.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo