Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Obese patients fare worse following diagnosis of colon cancer

University Of Chicago : 17 June, 2007  (Technical Article)
A new study shows that obese patients are more likely to have a recurrence of colon cancer than their normal-weight counterparts and face an increased risk of dying from the disease.
Dr. James J. Dignam of the University of Chicago and colleagues note that while it's not clear that losing weight would improve their prognosis, healthy lifestyle changes would probably have other beneficial effects for obese colon cancer patients.

There is strong evidence that being obese, defined as having a body mass index of 30 or greater, both increases the likelihood of developing colon cancer and worsens prognosis for individuals diagnosed with the disease, Dignam and his team report in the Journal of the National Cancer Institute.

To better understand the relationship between a patient's BMI and the outcome of chemotherapy for colon cancer, Dignam and his team looked at 4,288 colon cancer patients participating in two large nationwide clinical trials. The patients underwent surgery following a diagnosis of Dukes B or C colon cancer and all of the patients were randomly assigned to a chemotherapy regimen.

Subjects with a BMI of 35 or greater (defined as very obese) had a 38-percent risk of a tumor recurrence compared with normal weight individuals (those with a BMI of 18.5 to 24.9), the researchers found. The very obese were also 28 percent more likely to die during the 11.2-year follow-up period.

Underweight patients also had an elevated risk of death compared with those of normal weight, but most of their 49 percent increased death risk was due to causes unrelated to colon cancer.

The increased risk among the very obese could be related to the interplay between insulin, insulin-like growth factors and proteins that bind to these growth factors, Dignam and his colleagues suggest.

While more research is needed to determine if obese colon cancer patients will do better if they lose weight, they add, 'physicians might use the frequent encounters they have with these patients to counsel them regarding the possibility of modifying this risk with lifestyle changes.'

In any case, the researchers note, helping obese colon cancer patients eat better and become more active will likely have other benefits.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo