Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Why diet drug phen/fen damaged the heart

Case Western Reserve University : 02 January, 2001  (Technical Article)
Three years ago, the diet drug phen/fen was pulled from the market for causing heart valve damage. Fenfluramine, also known as dexfenflurmamine, the 'fen' part, was found to be the culprit.
Three years ago, the diet drug phen/fen was pulled from the market for causing heart valve damage. Fenfluramine, also known as dexfenflurmamine, the 'fen' part, was found to be the culprit.

A new study published in the December 5 issue of the American Heart Association's journal Circulation explains some of the underlying mechanisms about why the diet drug damaged the heart. Led by researchers from Case Western Reserve University's School of Medicine and the National Institute of Drug Abuse, the study screened fen, phentermine (phen), and several other drugs to see if they activated neurotransmitter receptors that can damage hearts.

Fen and two migraine drugs, ergotamine and methysergide, which also are known to cause heart valve damage, were found to activate the serotonin receptor known as 5-HT2B located on heart's valves (both the mitral and aortic). Serotonin is a neurotransmitter that affects a range of behaviors, including feeding, sleep and mood regulation.

According to Bryan L. Roth, associate professor of biochemistry, psychiatry and neurosciences at CWRU, and the paper's senior author, the findings suggest that activation of 5-HT2B receptors may be necessary to produce heart valve damage.

'The study points to a need for all potential medications to be screened to see if they engage the 5-HT2B receptor before passing approval. This is of great public health importance,' Roth said.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo