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IMPROVING THE IMMUNE SYSTEM USING 'CHATTY' BACTERIA
10 April 2002 - Society for General Microbiology
| Certain helpful bacteria are able to communicate with cells lining the gut causing the production of chemicals that can kill off harmful microbes when they try to invade, scientists heard at the spring meeting of the Society for General Microbiology at the University of Warwick. |
Certain helpful bacteria are able to communicate with cells lining the gut causing the production of chemicals that can kill off harmful microbes when they try to invade, scientists heard at the spring meeting of the Society for General Microbiology at the University of Warwick. "We have used various genetic and biochemical tests to see which intestinal genes are activated or repressed by the presence of bacteria. The normal gut bacterium Bacteroides thetaiotaomicron increases intestinal production of a protein that is toxic to some bacteria," says Dr Lora Hooper of Washington School of Medicine, USA. Dr Hooper explains, "We study the interaction of bacteria with the intestine by looking at mice raised under sterile conditions so that they are completely free from bacteria. We then add B. thetaiotaomicron back on its own so that we can listen to the communication between the microbe and the human gut cells." The human intestine is home to over 1 kg in weight of bacteria. These microbes perform vital roles in vitamin production; digestion and absorption of nutrients; and helping to educate and shape our immune system. "Scientists are looking for different ways to fight infections due to the growing number of antibiotic resistant bacteria. Our research shows that it may be possible to improve a person's resistance to certain infections just by increasing the numbers of certain beneficial microbes," says Dr Hooper.
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About: Society for General Microbiology
The Society for General Microbiology is the largest microbiology society in Europe, and has over 5,500 members worldwide. The Society provides a common meeting ground for scientists working in research and in fields with applications in microbiology including medicine, veterinary medicine, pharmaceuticals, industry, agriculture, food, the environment and education.The SGM represents the science and profession of microbiology to government, the media and the general public; supporting microbiology education at all levels; and encouraging careers in microbiology. |
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