Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Bone marrow cells can produce epithelial cells without fusion

Yale University : 02 July, 2004  (New Product)
Led by Diane Krause, associate professor of Laboratory Medicine and Pathology at Yale School of Medicine, the investigators transplanted marrow-derived cells from male mice into female mice. They followed the fate of the marrow-derived cells (male) by detecting the Y chromosome. If resulting epithelial cells were formed by cell-to-cell fusion, they should express green fluorescent protein and not beta-galactosidase.
Epithelial cells derived from bone marrow cells can be a result of differentiation, not fusion, according to a study published in Science by Yale researchers who arrived at some of the earliest findings on non-blood cells derived from bone marrow.

Led by Diane Krause, associate professor of Laboratory Medicine and Pathology at Yale School of Medicine, the investigators transplanted marrow-derived cells from male mice into female mice. They followed the fate of the marrow-derived cells (male) by detecting the Y chromosome. If resulting epithelial cells were formed by cell-to-cell fusion, they should express green fluorescent protein and not beta-galactosidase.

'Our results show that under normal circumstances, the green fluorescent protein was not expressed, which means that no fusion has occurred and that the marrow derived cells can become non-blood cells without fusing,' said Krause, attending physician in Laboratory Medicine at Yale-New Haven Hospital.

Krause said they did find that when the tissues were damaged, there were some cells that expressed GFP and therefore were derived from donor cells fusing with recipient cells.

Several years ago Krause's laboratory published a study showing that bone marrow stem cells can differentiate into liver, lung, kidney, skin, muscle and other cells. Later studies published by other researchers postulated that the bone marrow derived cells had actually fused with epithelial cells.

Krause said the ramifications of these latest findings are still unclear. 'The absence of fusion in this model does not necessarily imply that trans-differentiation, a change in phenotype of one mature cell type to that of another mature cell type, has occurred,' she said. 'In fact, we carefully refrain from using that terminology in this report to avoid making assumptions about the mechanism of the phenotypic change.'

She said it may be that an as-yet-unidentified, multipotent epithelial precursor exists in the bone marrow or that a separate population of marrow precursors exhibit a gene expression pattern that can be reprogrammed to express markers of other cell types.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo