Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Finding about cellular microtubule rigidity could lead to development of new nano-materials

University Of Texas At Austin : 10 July, 2006  (Technical Article)
Microtubules, essential structural elements in living cells, grow stiffer as they grow longer, an unexpected property that could lead to advances in nano-materials development, an international team of biophysicists has found.
Microtubules, essential structural elements in living cells, grow stiffer as they grow longer, an unexpected property that could lead to advances in nano-materials development, an international team of biophysicists has found.

The team, from The University of Texas at Austin, the European Molecular Biology Laboratory in Heidelberg, Germany, and Ludwig Maximilians University of Munich, reported their findings in Proceedings of the National Academy of Science on July 5.

“We found that the microtubules grow stiffer as they grow longer, a very unusual and surprising result,” said Ernst-Ludwig Florin, assistant professor with the Center for Nonlinear Dynamics at The University of Texas at Austin. “This will have a big impact on our understanding of how microtubules function in the cell and on advancing materials research.

“To my knowledge, no manmade material has this property, to become stiffer as it elongates,” said Florin. “This research could lead to the design of novel materials based on this biological structure.”

Microtubules, which are about 25 nanometers in diameter, play an essential role in many cellular processes, acting as girders of support for the cell and tracks along which organelles, structures in cells that perform specialized functions, can move. They are also essential components of flagella and cilia, the extensions of some cells that give them movement.

Florin and his colleagues measured the stiffness and length of cellular microtubules using a “single-particle tracking” technique. They attached yellow-green fluorescent beads to the tips of microtubules of various lengths and measured the position of the bead by analyzing frame-by-frame videos of the beads moving in solution. (The beads were 250 or 500 nanometers in diameter.)

The changes in the beads’ position were used to calculate the stiffness of the filaments they were attached to, through a method recently developed by the theoretical physicists on the research team.

To the surprise of the scientists, they found that the longer the filament, the more rigid it became.

Florin and his coauthors attribute the microtubules’ unique properties to their molecular architecture. The nanometer-sized filaments are hollow tubes made of tubulin proteins that bind to each other in ways that give them the ability to be both flexible and stiff.

Flexibility is important for microtubules as they grow and change in cells, while rigidity is important when cells need support.

“Microtubules are optimally designed to give the maximum of mechanical performance at a minimum cost for the cell,” said Francesco Pampaloni, a physical chemist at EMBL.

The new finding about the microtubules’ properties could provide insights into using the filaments as models for the development of nano-materials.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   Â© 2012 NewMaterials.com
Netgains Logo