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News

Molecule important in cell construction also critical in learning and memory

Yale University : 01 March, 2005  (New Product)
A family of proteins that help build the cytoskeleton, or the bones of the cell, also play an important role in learning and memory, according to a study published this month in The Journal of Neuroscience.
A family of proteins that help build the cytoskeleton, or the bones of the cell, also play an important role in learning and memory, according to a study published this month in The Journal of Neuroscience.

Marina Picciotto, associate professor of psychiatry, pharmacology and neurobiology at Yale School of Medicine, and the senior author of the study, studied mice missing one of these proteins, ߖadducing, and found the cytoskeleton developed normally. However, the mice were impaired during fear conditioning and memory exercises.

'We were hoping to find a mechanism that cells use to make short term changes in nerve cell communication permanent, but we were surprised that losing ߖadducin made such a big change in both the nerve cell communication and in behavioral measures of memory,' Picciotto said.

The focus of the study is longterm potentiation, which is a form of neuronal plasticity and may form the biological basis for some kinds of memory. Longterm potentiation refers to the fact that if two neurons in the hippocampus are active at the same time, the connection between them can be strengthened. This change, or potentiation, can last for hours to days. This may serve to lay a foundation for more permanent changes, such as the construction of new connections, or synapses, between the neurons.

'If you learn to do something new, your neurons have to adapt and change to create a stronger, more direct pathway between neurons,' Picciotto said. 'The protein ߖadducin appears to be important for making those new connections.'
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