Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

MRSA infection risk for people in hospitals

University Of Chicago : 20 June, 2007  (Technical Article)
According to scientists, a vaccine to guard against hospital superbug MRSA is a step closer. US researchers have developed a vaccine that protected mice from four potentially deadly strains of MRSA.
Writing in the Proceedings of the National Academy of Sciences, the team said the study could lead to a human vaccine, though more work was needed.

Methicillin-resistant Staphylococcus aureus often strikes in hospitals where patients' immune systems are weak.

This microbe's ability to acquire the tools it needs to protect itself from the drugs we use to treat it is legendary

It is difficult to fight because it has developed a resistance to certain antibiotics.

The team looked for a vaccine using a technique called 'reverse vaccinology', which builds on recent genetics advances.

It involved sifting through the genome of Staphylococcus aureus to hunt for proteins on the microbe that might spark the body's immune system into action, producing protection against the bacteria.

The team identified four proteins that prompted a strong immune response, making them good targets for vaccines.

When they combined the different proteins and injected them into laboratory mice, they discovered the mice had gained protection against five different strains of Staphylococcus aureus.

Four of these strains were MRSA, while the other was a strain associated with toxic shock after burn injuries.

The vaccine gave the mice between 60% and 100% immunity.

The team said further tests would be needed to understand the mechanism of the vaccine and to discover if it would be as effective in humans.

Lead researcher Olaf Schneewind, professor of microbiology at the University of Chicago, said: 'This microbe's ability to acquire the tools it needs to protect itself from the drugs we use to treat it is legendary, which is why a vaccine has become such a high priority.

'One by one, this organism has learned how to evade nearly all of our current antibiotics. So, generating protective immunity against invasive S aureus has become an important goal.'

But Dr Jodi Lindsay, senior lecturer at the Centre of Infection at St George's, University of London, said: 'I think this study has not discussed some important things.

'The researchers did not look at a good cross-section of strains of MRSA - there are several families of MRSA, each containing many different strains, and the team only looked at a few US-specific strains.'

She added that, for a vaccine to be efficient across a number of different strains, the proteins used must be the same in every strain but the proteins used in the experiments varied.

'It is also important to remember a mouse model is not the same as a human model. The hard bit is getting a vaccine from a mouse to a human, because that involves a lot of patients, a lot of money, a lot of regulation, and so far, the best examples have failed.'
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo