Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Studies Find Possible Drug Targets for Improving Vascular Health

Yale University : 25 August, 2005  (New Product)
The enzyme nitric oxide synthase plays a role in peripheral vascular disease, a common disease that impairs the mobility of 25 percent of people over the age of 50, according to a Yale study in the Proceedings of the National Academy of Sciences.
In a related study this month in the Journal of Clinical Investigation, the same investigator, William Sessa, professor of pharmacology at Yale School of Medicine, found that the protein kinase, Akt1, one of three Akt molecules involved in growth, survival, metabolism and other cellular functions, is responsible for enhancing new blood vessel growth following a blockage due to ischemia.

In the PNAS study Sessa used mice missing the endothelial nitric oxide synthase gene and found they had impaired ability to build arteries and capillaries, which are important for providing blood flow to muscle upon exercise training. Sessa and his colleagues also succeeded in using gene therapy to reverse the effects of the missing gene, which rescued limbs in danger of dying because of ischemia. Ischemia is a severe reduction of blood flow and nutrients, usually because of a blood clot or atherosclerosis.

Sessa said the study in PNAS implies that therapeutic approaches to improve blood flow and arteriogenesis in patients with peripheral vascular disease by using a single cytokine will have limited utility unless impairments in the enzyme nitric oxide function are taken into account and corrected.

His study on the Akt1 molecule is believed to provide the first direct evidence that changes in capillary formation and vascular leakage induced by the angiogenic factor vascular endothelial growth factor requires Akt1. VEGF is produced by ischemic tissue, as well as tumor cells, to stimulate the formation of new blood vessels. The data also suggest that inhibition of Akt1 signaling may be an effective strategy to block not only tumor growth, but the pathological growth of new blood vessels from existing blood vessels that are mediated by vascular endothelial growth factor. However, Sessa said, this strategy may be a 'double-edged sword' since inhibition of Akt may also worsen peripheral vascular disease secondary to atherosclerosis, diabetes or aging. The studies in PNAS and JCI are synergistic since Akt can regulate nitric oxide synthase function by increasing its activity.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo