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USC study supports origin of cancer

University Of Southern California : 16 May, 2007  (Technical Article)
Permanent silencing of genes prevents embryonic stem cells from differentiating, leading to the seeds of cancer development later in life, researcher says. Peter Laird, associate professor at the Keck School of Medicine of USC, and researchers found empirical evidence for a stem cell origin of cancer.
Researchers at USC recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development.

According to the study’s findings, which appear in an upcoming issue of Nature Genetics and are now available online, genes that are reversibly repressed in embryonic stem cells are over-represented among genes that are permanently silenced in cancers. This link lends support to the increasingly discussed theory that cancer is rooted in small populations of stem cells.

USC researchers uncovered this link after observing that of 177 genes repressed by Polycomb group proteins, fully 77 showed evidence of cancer-associated enzymatic modification of DNA (known as methylation).

“Finding that a Polycomb target in an embryonic stem cell is 12 times more likely to become abnormally methylated in cancer is highly significant,” said Peter Laird, one of the lead researchers and associate professor of surgery, biochemistry and molecular biology, and director of basic research for surgery at the Keck School of Medicine of USC.

Laird and his colleagues discovered that some genes repressed by Polycomb in embryonic stem cells are essentially premarked to become permanently silenced by DNA methylation.

“This permanent silencing prevents embryonic stem cells from differentiating, and they thus become the seeds of cancer development later in life,” Laird explained.

USC researchers made these observations in relation to breast, colorectal, lung and ovarian cancer.

Not only does the USC study provide empirical evidence for a stem cell origin of cancer, but, according to Laird, “It also supports a very early involvement of epigenetics in cancer.

“We found that cancer arises in cells that have already undergone epigenetic alterations,” he added, “which points to epigenetic events preceding genetic events in cancer development.”

Laird noted that this theory, while relatively new, is gaining support among scientists.

Findings from the USC study also can be applied to stem cell research funded by the California Institute for Regenerative Medicine, which was created through passage of California Proposition 71.

“One of [the institute’s] aims is to culture and differentiate embryonic stems cells, cells that would then be placed into patients,” Laird said. “Since our research shows that cancer is rooted in stem cells, it would be very important to screen for the epigenetic abnormalities that we uncovered, so as to prevent people from receiving potentially cancer-prone cells.”

Looking ahead, Laird and his USC colleagues would next like to focus on what causes some genes to transition from temporary repression to permanent silencing.

Laird collaborated with colleagues at USC and England’s University College London.

This work was supported by grants from the European Union and from the FWF Austrian Science Fund awarded to Martin Widschwendter and by a National Institutes of Health grant awarded to Laird.
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