Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Yale researchers develop new molecule that eradicates cancer by destroying tumor blood vessels

Yale University : 02 October, 2001  (New Product)
Researchers at Yale have developed a new molecule they call 'icon' that targets blood vessels in tumors for destruction by the immune system without harming vessels in normal tissues.
'Our study resulted in the eradication of injected tumors and also of other tumors in mice that had not been injected,' said principal investigator Alan Garen, professor of molecular biophysics and biochemistry at Yale University. 'This serves as a model of metastatic cancer. None of the normal tissues in the mouse appeared to be harmed by our procedure.'

Published in the October 9 issue of Proceedings of the National Academy of Sciences, the study was conducted with human melanoma and prostate tumors growing in mice. The gene for the icon was inserted into an adenovirus vector that was injected into a tumor, resulting in the infection of tumor cells that act within the mice as factories for producing the icon and secreting it into the blood.

Garen said that in order to target tumor blood vessels without harming the normal blood vessels, a molecule that is expressed specifically on the inner surface of the tumor is needed. The molecule used for this study is called tissue factor, whose normal function is to initiate blood clotting.

Blood clotting occurs when another molecule called factor VII, which circulates constantly in the blood, binds to tissue factor. The binding of factor VII to tissue factor is one of the strongest and most specific interactions known in biology. Garen and Yale research scientist Zhiwei Hu, constructed the icon, which is modeled after a camel's version of an antibody. The icon is composed of two parts. One part targets the icon to tissue factor by using factor VII as the targeting domain. The other part of the icon is the region of a natural antibody that activates an attack by the immune system against cells that bind to the icon.

'The result is that the tumor blood vessels are destroyed by the immune system and consequently the tumor cells die because they lack a blood supply,' said Garen. 'The normal blood vessels survive because they do not express tissue factor and therefore do not bind the icon.'

'This icon should work against all types of tumors that contain blood vessels,' said Garen. 'The icon that will be used in a clinical trial is derived entirely from human components and therefore should not be significantly immunogenic, which is an advantage over antibodies used in this kind of study.'

Garen said the procedure could also be effective against other diseases that require growing blood vessels, such as macular degeneration, the major cause of blindness in older people.

A clinical trial is being arranged by Albert Deisseroth, M.D., formerly of Yale, and currently President of the Sidney Kimmel Cancer Center in San Diego.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo