Free Newsletter
Register for our Free Newsletters
Newsletter
Zones
Advanced Composites
LeftNav
Aerospace
LeftNav
Amorphous Metal Structures
LeftNav
Analysis and Simulation
LeftNav
Asbestos and Substitutes
LeftNav
Associations, Research Organisations and Universities
LeftNav
Automation Equipment
LeftNav
Automotive
LeftNav
Biomaterials
LeftNav
Building Materials
LeftNav
Bulk Handling and Storage
LeftNav
CFCs and Substitutes
LeftNav
Company
LeftNav
Components
LeftNav
Consultancy
LeftNav
View All
Other Carouselweb publications
Carousel Web
Defense File
New Materials
Pro Health Zone
Pro Manufacturing Zone
Pro Security Zone
Web Lec
Pro Engineering Zone
 
 
 
News

Yale researchers discover a genetic cause of high blood pressure

Yale University : 09 August, 2001  (New Product)
Researchers at Yale studying a rare inherited form of hypertension have discovered mutations in two different genes that can cause this disease, clearing the way for new medications to treat both the rare and common forms of high blood pressure.
'This study identifies a previously unknown biochemical pathway involved in the regulation of blood pressure,' said principal investigator Richard P. Lifton, M.D., professor of genetics, medicine, and molecular biophysics and biochemistry at Yale School of Medicine. 'These findings raise the possibility that new medications affecting the activity of this pathway might be effective for treating high blood pressure and congestive heart failure.'

Published in the August 10 issue of Science, the study is the most recent in a series by Lifton and his team looking at the genetics of hypertension (high blood pressure), which affects 25 percent of most adult populations and is an important risk factor for death from stroke, heart attack and kidney failure.

Lifton and his team used genetic analysis to identify the underlying cause of a rare form of hypertension called pseudohypoaldosteronism type II in 20 families from around the world. PHAII causes high blood pressure as well as an inability to eliminate potassium and hydrogen ions from the body. The team identified two genes that can cause the disease. Both of these genes are members of a newly identified family of proteins that regulate the activity of other proteins with the addition of phosphate groups.

Lifton said both proteins are located in a part of the kidney that is involved in the regulation of salt, potassium and pH balance. High blood pressure arises from these proteins, causing increased salt reabsorption in the kidneys and diminished secretion of potassium and hydrogen.

Lifton said one of the mutated genes he and his team discovered maps to a chromosome segment that has previously been implicated in the common form of hypertension, called essential hypertension. 'This raises the possibility that more common variants in this same gene might contribute to hypertension in the general population,' he said.

Lifton and his team are working with the Framingham heart study to examine the role that these newly discovered genes play in blood pressure variation in the general population. He said these new findings pave the way for better understanding of the basic causes of this common disease as well as the promise for new and improved treatments.
Bookmark and Share
 
Home I Editor's Blog I News by Zone I News by Date I News by Category I Special Reports I Directory I Events I Advertise I Submit Your News I About Us I Guides
 
   © 2012 NewMaterials.com
Netgains Logo